1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism


Cat. No.: HY-B1756 Purity: >98.0%
Handling Instructions

Rotenone is an mitochondrial electron transport chain complex I inhibitor.

For research use only. We do not sell to patients.

Rotenone Chemical Structure

Rotenone Chemical Structure

CAS No. : 83-79-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 108 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Rotenone is an mitochondrial electron transport chain complex I inhibitor.

In Vitro

Mitogen Activated Protein Kinase (MAPK), Toll-like receptor, Wnt, and Ras signaling pathways are intensively involved in the effect of rotenone on the ENS[2]. Rotenone-induced cell death is reduced by MCE treatment as measured by decline in the levels of pro-apoptotic proteins. Moreover, MCE treatment significantly augments the levels of anti-apoptotic Bcl2 and blocks the release of cytochrome c, thereby alleviating the rotenone-induced dopaminergic neuronal loss, as evidenced by tyrosine hydroxylase (TH) immunostaining in the striatum[3].

In Vivo

Rotenone causes a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine are observed in the cerebellum of rat model of PD[1]. Rotenone (1.5, 2, or 2.5 mg/kg) causes a dose-dependent increase in α-synuclein in the substantia nigra. Furthermore, at 2 and 2.5 mg/kg, rotenone causes a significant decrease in the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra, and dopamine in the striatum in rats[4].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5354 mL 12.6768 mL 25.3537 mL
5 mM 0.5071 mL 2.5354 mL 5.0707 mL
10 mM 0.2535 mL 1.2677 mL 2.5354 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C1[[email protected]]2([H])[[email protected]](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C(O[[email protected]@H](C(C)=C)C5)=CC=C14

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Cat. No.: HY-B1756