2. Natural Products
  3. Plants
  4. Leguminosae
  5. Derris trifoliata Lour.

Derris trifoliata Lour.

Derris trifoliata Lour. (11):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1756
    Rotenone 83-79-4 99.9%
    Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone
  • HY-13425
    Deguelin 522-17-8 99.20%
    Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
    Deguelin
  • HY-B1756R
    Rotenone (Standard) 83-79-4
    Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone (Standard)
  • HY-121811
    Pongamol 484-33-3 99.81%
    Pongamol (Lanceolatin C) is an orally active flavonoid with an IC50 of 75 μM and a Ki of 58 μM against PTPase-1B, and an IC50 of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2 and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia.
    Pongamol
  • HY-13425R
    Deguelin (Standard) 522-17-8
    Deguelin (Standard) is the analytical standard of Deguelin. This product is intended for research and analytical applications. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
    Deguelin (Standard)
  • HY-N11730
    6',7'-Epoxyrotenone 36375-25-4
    6',7'-Epoxyrotenone is a derivative and photodegradation product of Rotenone (HY-B1756), with an acute intraperitoneal LD50 of 7.2 mg/kg in mice.
    6',7'-Epoxyrotenone
  • HY-N11732
    O-Demethylrotenone 36375-21-0
    O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD50 of O-Demethylrotenone in Mus musculus is 8.0 mg/kg.
    O-Demethylrotenone
  • HY-N7297
    Derrisisoflavone K 2172624-68-7
    Derrisisoflavone K is a natural product.
    Derrisisoflavone K
  • HY-N7298
    Derrisisoflavone J 2172624-67-6
    Derrisisoflavone J is a natural product.
    Derrisisoflavone J
  • HY-N7299
    Derrisisoflavone I 2172624-66-5
    Derrisisoflavone I is a natural product.
    Derrisisoflavone I
  • HY-N7296
    Derrisisoflavone H 2172624-65-4
    Derrisisoflavone H is a natural product.
    Derrisisoflavone H