SgK495

SgK495, or Sugen kinase 495, is a poorly characterized protein identified during the Sugen receptor kinase cloning program as a putative serine/threonine kinase with a catalytic domain related to the CAMK family. Its sequence contains the conserved subdomains and catalytic residues expected of an active kinase, but physiological activators, substrates, and calmodulin sensitivity have not been convincingly demonstrated. Expression appears broadly detectable at low levels, yet no genetic disease or strong cancer association has been assigned. SgK495 is retained in kinome catalogues as a distinct lineage, exemplifying the orphan kinases whose biological functions still await systematic functional genomics, localization, and substrate-mapping studies.