Histamine Receptor

Related Products

Histamine Receptors are a class of G protein-coupled receptors with histamine as their endogenous ligand. There are four known histamine receptors: H1 receptor, H2 receptor, H3 receptor, H4 receptor. The H1 receptor is a histamine receptor belonging to the family of Rhodopsin-like G-protein-coupled receptors. This receptor, which is activated by the biogenic amine histamine, is expressed throughout the body, to be specific, in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. H2 receptors are positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production, which leads to activation of Protein Kinase A. Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act asautoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release. The Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cell chemotaxis.

Histamine Receptor Related Products (123):

By Effects:	Inhibitors (41) Agonists (3) Antagonists (74) Activators (1) Modulators (2)

Cat. No.	Product Name	Effect	Purity

HY-17043

Loratadine Agonist 99.95%

Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Loratadine	Agonist	99.95%
Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

HY-B1204

Histamine	Activator	99.96%
Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

HY-N0054

Osthole Inhibitor 99.90%

Osthole is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity.
HY-14289

Cimetidine Antagonist >98.0%

Cimetidine is a histamine-2 (H2) receptor antagonist.
HY-B0298A

Clemastine fumarate Antagonist 99.82%

Clemastine (fumarate) (HS-592 (fumarate)) is a selective histamine H1 receptor antagonist with IC₅₀ of 3 nM.

Osthole	Inhibitor	99.90%
Osthole is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity.

Cimetidine	Antagonist	>98.0%
Cimetidine is a histamine-2 (H2) receptor antagonist.

Clemastine fumarate	Antagonist	99.82%
Clemastine (fumarate) (HS-592 (fumarate)) is a selective histamine H1 receptor antagonist with IC₅₀ of 3 nM.

HY-111501

H4R antagonist 1	Antagonist
H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC₅₀ of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.

HY-114025

H4 Receptor antagonist 1 Inhibitor 99.70%

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC₅₀ of 19 nM.
HY-15538

Ebrotidine Antagonist

Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5 nM) with a potent antisecretory activity and evidenced gastroprotection.
HY-13508

JNJ-7777120 Antagonist 99.96%

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.
HY-12199B

Pitolisant hydrochloride Antagonist 99.22%

Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (K_i=0.16 nM).
HY-14270

Lodoxamide Inhibitor 98.00%

Lodoxamide is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.
HY-B0377

Famotidine Antagonist 98.17%

Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
HY-B0157A

Ketotifen fumarate Inhibitor 99.92%

Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.

H4 Receptor antagonist 1	Inhibitor	99.70%
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC₅₀ of 19 nM.

Ebrotidine	Antagonist
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5 nM) with a potent antisecretory activity and evidenced gastroprotection.

JNJ-7777120	Antagonist	99.96%
JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

Pitolisant hydrochloride	Antagonist	99.22%
Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (K_i=0.16 nM).

Lodoxamide	Inhibitor	98.00%
Lodoxamide is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

Famotidine	Antagonist	98.17%
Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Ketotifen fumarate	Inhibitor	99.92%
Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.

HY-B0801A

Fexofenadine hydrochloride	Inhibitor	99.61%
Fexofenadine is a third-generation antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria.

HY-15289

Ciproxifan maleate	Antagonist	99.56%
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

HY-A0129

Histamine phosphate Agonist 99.40%

Histamine diphosphate is a potent agonist of histamine receptors and vasodilator. It can activate nitric oxide synthetase.
HY-B0539

Desloratadine Antagonist 99.75%

Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.

Histamine phosphate	Agonist	99.40%
Histamine diphosphate is a potent agonist of histamine receptors and vasodilator. It can activate nitric oxide synthetase.

Desloratadine	Antagonist	99.75%
Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.

HY-B0164

Mizolastine	Antagonist	99.33%
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

HY-B0349

Meclizine dihydrochloride	Antagonist	99.97%
Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness Target: Histamine H1 Receptor Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, possesses anticholinergic, central nervous system depressant, and local anesthetic effects [1].

HY-17042A

Cetirizine dihydrochloride	Inhibitor	99.17%
Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

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