1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Cetirizine

Cetirizine 

Cat. No.: HY-17042
Handling Instructions

Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.

For research use only. We do not sell to patients.

Cetirizine Chemical Structure

Cetirizine Chemical Structure

CAS No. : 83881-51-0

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Top Publications Citing Use of Products

    Cetirizine purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
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    Description

    Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

    In Vitro

    Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo
    Clinical Trial
    Molecular Weight

    388.89

    Formula

    C₂₁H₂₅ClN₂O₃

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Solvent & Solubility
    In Vivo:
    • 1.

      Cetirizine is dissolved in PBS[6].

    References
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    Cetirizine
    Cat. No.:
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