1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor
  3. Cetirizine

Cetirizine 

Cat. No.: HY-17042
Handling Instructions

Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

For research use only. We do not sell to patients.

Cetirizine Chemical Structure

Cetirizine Chemical Structure

CAS No. : 83881-51-0

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100 mg USD 60 Get quote
200 mg USD 96 Get quote
500 mg USD 120 Get quote

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Top Publications Citing Use of Products

    Cetirizine purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
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    Description

    Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. IC50 value: Target: Histamine H1 receptor Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.

    Clinical Trial
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    Molecular Weight

    388.89

    Formula

    C₂₁H₂₅ClN₂O₃

    CAS No.

    83881-51-0

    SMILES

    O=C(O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1

    Shipping

    Room temperature in continental US; may vary elsewhere

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    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Cetirizine
    Cat. No.:
    HY-17042
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    Cetirizine

    Cat. No.: HY-17042