1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Minoxidil

Minoxidil (Synonyms: U10858)

Cat. No.: HY-B0112 Purity: 99.96%
Handling Instructions

Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM.

For research use only. We do not sell to patients.

Minoxidil Chemical Structure

Minoxidil Chemical Structure

CAS No. : 38304-91-5

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in Ethanol USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 130 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

IC50 & Target

IC50: 20 μM (soybean lipoxygenaseare)[1]; ATP-sensitive potassium channel[2]

In Vitro

Minoxidil (1-00 µM; 24 hours; RAMEC cells) treatment shows very low cytotoxicities in the whole area of concentrations examined (from 1 µM to 100 µM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fisher 344 rats (150-200 g) with oedema[1]
Dosage: 0.01 mmol/kg body weight
Administration: Intraperitoneal injection; for 3.5 hours
Result: Inhibition of the carrageenin-induced oedema.
Clinical Trial
Molecular Weight

209.25

Formula

C₉H₁₅N₅O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 7.14 mg/mL (34.12 mM; Need ultrasonic)

H2O : 1 mg/mL (4.78 mM; ultrasonic and warming and heat to 50°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7790 mL 23.8949 mL 47.7897 mL
5 mM 0.9558 mL 4.7790 mL 9.5579 mL
10 mM 0.4779 mL 2.3895 mL 4.7790 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  50% PEG300    50% saline

    Solubility: 5 mg/mL (23.89 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.71 mg/mL (3.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.71 mg/mL (3.39 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 0.71 mg/mL (3.39 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (2.39 mM); Clear solution

  • 6.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (2.39 mM); Clear solution

  • 7.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (2.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Minoxidil
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HY-B0112
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