1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. CRM1

CRM1

Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (eg, p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therapeutic strategy to restore tumor suppressor function. Orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein have been recently developed.

CRM1 is the sole exporter of many tumor-suppressor proteins (TSPs), and functions as a proto-oncogene by transporting these tumor suppressors from the nucleus, where they are active, to the cytoplasm, where their activity is abrogated.

CRM1 Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-16909
    Leptomycin B Inhibitor >98.0%
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
  • HY-100423A
    Eltanexor Z-isomer Inhibitor
    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.
  • HY-108716
    CBS9106 Inhibitor
    CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.