CRM1-IN-1
CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 3032506-80-9
- Formula: C29H48N2O5
- Molecular Weight:504.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.12 μM
Compound: KL1
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 37595020] |
| RKO | IC50 |
0.19 μM
Compound: KL1
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Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 37595020] |
Chemical Information
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CAS No. 3032506-80-9
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Molecular Weight 504.70
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Formula C29H48N2O5
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SMILES
[H][C@]1([C@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CRM1-IN-1 Related Classifications
HY-155972 Related Classifications
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