3032506-80-9
3032506-80-9
Chemical Structure
CRM1-IN-1
- CAS No.: 3032506-80-9
- Formula:C29H48N2O5
- Molecular Weight:504.70
InChIKey: PLLUXUKFSITXBR-KXXVXRNASA-N
SMILES: [H][C@]1([C@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
Biological Activity: CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells[1].
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CRM1-IN-1 | CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells. | |||||||||||||||||||||
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