2. Recombinant Proteins
  3. Receptor Proteins
  4. Siglec

Siglec

Related Products

XLSX 6.32 KB

Sialic acid-binding Immunoglobulin-like lectins (Siglecs) are cell-surface I-type lectins that act as immunomodulatory sialic acid-binding receptors. Siglecs belong to the Immunoglobulin (Ig) superfamily. They are expressed on various immune cells that include immune cells of both lymphoid and myeloid origin, namely neutrophils, eosinophils, monocytes, macrophages, NK cells, DCs, mast cells, and B and T cells. All Siglecs are single-pass type 1 integral membrane proteins containing extracellular domains with one (or two, in the case of Siglec-12) unique and homologous N-terminal V-set Ig domain, followed by variable numbers of C2-set Ig domains, ranging from 16 in sialoadhesin to 1 in CD33. Based on sequence homologies,the Siglecs can be divided into two groups: one including all CD33-related Siglecs and the other consisting of Siglec-1 (Sialoadhesin), Siglec-2 (CD22), Siglec-4 (myelin-associated glycoprotein, MAG) and Siglec-15.

Subscribe Now to the List of Recombinant Proteins

 
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity