1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Serine/Threonine Kinase Proteins

Serine/Threonine Kinase Proteins

Protein kinases control metabolism, transcription, cell division and movement, programmed cell death, and they participate in the immune response and nervous system function. Protein phosphorylation involves the balanced action of protein kinases and phosphoprotein phosphatases making phosphorylation-dephosphorylation an overall reversible process. According to amino acid residues of proteins that are phosphorylated, the protein kinases are classified into the following families:Serine/threonine protein kinases,Tyrosine-specific protein kinases,Histidine-specific protein kinases,Tryptophan kinase,Aspartyl/glutamyl protein kinase. Serine/threonine protein kinases are protein kinases which catalyze the phosphorylation of serine or threonine residues on target proteins by using ATP as phosphate donor. Serine/threonine protein kinases include cyclin-dependent kinase, mitogen-activated protein kinase (MAPK), protein kinase D, nattokinase, DNA-dependent protein kinase, Aurora protein kinases, pancreatic kininogenase.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72812
    Activin RIA Protein, Human (HEK293, His-Fc)

    Activin receptor type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2

    Human HEK293
    Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Activin RIA Protein, Human (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag . It consists of 124 amino acids (M1-V124).
  • HY-P72813
    ACVR2B Protein, Human (HEK293, Fc)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Human HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).
  • HY-P73428
    TGFBR2/TGF-beta RII Protein, Human (sf9, His)

    TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II

    Human Sf9 insect cells
    The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (sf9, His) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Human (sf9, His) is 144 a.a., with molecular weight of ~24 kDa.
  • HY-P74522
    TGFBR1/ALK-5 Protein, Human (sf9, His-GST)

    TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5

    Human Sf9 insect cells
    TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is 304 a.a., with molecular weight of ~57 kDa.
  • HY-P76550
    PLK1 Protein, Human (sf9, His)

    Serine/threonine-protein kinase PLK1; PLK-1; STPK13

    Human Sf9 insect cells
    PLK1 is a serine/threonine protein kinase that centrally coordinates key functions during the M phase of the cell cycle. It regulates centrosome maturation, spindle assembly, cohesin removal, inactivates APC/C inhibitors, and controls mitotic exit and cytokinesis. PLK1 Protein, Human (sf9, His) is the recombinant human-derived PLK1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PLK1 Protein, Human (sf9, His) is 603 a.a., with molecular weight of ~66 kDa.
  • HY-P78215
    TGFBR2/TGF-beta RII Protein, Human (Biotinylated, HEK293, Fc-Avi)

    TGFR2; TGFBR2; TbetaR-II; TGFβR2; TbetaR-II; TGFβR2; AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TβR-II; TβR-II

    Human HEK293
    The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Human (Biotinylated, HEK293, Fc-Avi) is 136 a.a., with molecular weight of 55-70 kDa.
  • HY-P78524
    TGFBR2/TGF-beta RII Protein, Human (HEK293, mFc-Avi)

    TGFR2; TGFBR2; TbetaR-II; TGFβR2; TbetaR-II; TGFβR2; AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TβR-II; TβR-II

    Human HEK293
    The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (HEK293, mFc-Avi) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Human (HEK293, mFc-Avi) is 136 a.a., with molecular weight of 55-70 kDa.
  • HY-P78525
    TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi)

    AAT5; ACVRLK4; ALK-5; LDS1A; LDS2A; SKR4; tbetaR-I; TGFB1R1; TGF-beta RI; TGFbetaRI; TGFBR1; TGF-bRI; TGFR-1; tβR-I; TGF-β RI; TGFβRI

    Human HEK293
    TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi) is 92 a.a., with molecular weight of 50-60 kDa.
  • HY-P73282
    LOK Protein, Human (His)

    Serine/threonine-protein kinase 10; STK10; LOK

    Human E. coli
    LOK is an important serine/threonine protein kinase that significantly regulates lymphocyte migration by phosphorylating MSN and potentially PLK1. It acts as a negative regulator of MAP3K1/MEKK1. LOK Protein, Human (His) is the recombinant human-derived LOK protein, expressed by E. coli , with N-His labeled tag. The total length of LOK Protein, Human (His) is 300 a.a., with molecular weight of ~40 kDa.
  • HY-P73430
    TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)

    TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II

    Rat HEK293
    TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is 166 a.a., with molecular weight of ~54 kDa.
  • HY-P73858
    IRE1 Protein, Human (sf9)

    Serine/threonine-protein kinase/endoribonuclease IRE1; IRE1a; ERN1; IRE1

    Human Sf9 insect cells
    IRE1 is a key serine/threonine protein kinase and endoribonuclease essential for sensing the unfolded protein response (UPR) in the endoplasmic reticulum. In cellular homeostasis, it remains monomeric by binding to HSPA5/BiP. IRE1 Protein, Human (sf9) is the recombinant human-derived IRE1 protein, expressed by Sf9 insect cells , with tag free. The total length of IRE1 Protein, Human (sf9) is 513 a.a., with molecular weight of ~65 kDa.
  • HY-P74114
    GSK-3 beta Protein, Human (sf9, His)

    Glycogen synthase kinase-3 beta; GSK-3 beta; Gsk3b

    Human Sf9 insect cells
    The TrkA protein is a receptor protein that binds to the neurotrophin nerve growth factor (NGF). It plays a crucial role in the development and survival of neurons. GSK-3 beta Protein, Human (sf9, His) is the recombinant human-derived GSK-3 beta protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of GSK-3 beta Protein, Human (sf9, His) is 433 a.a., with molecular weight of 44-48 kDa.
  • HY-P74742
    MST1/STK4 Protein, Human (sf9, His)

    Serine/threonine-protein kinase 4; MST1/N; MST1/C; STK4; KRS2

    Human Sf9 insect cells
    MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. MST1/STK4 Protein, Human (sf9, His) is the recombinant human-derived MST1/STK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of MST1/STK4 Protein, Human (sf9, His) is 486 a.a., with molecular weight of ~58 kDa.
  • HY-P75536
    ACVR2B Protein, Mouse (HEK293, His)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Mouse HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-T134).
  • HY-P75563
    ACVR2A/Activin RIIA Protein, Mouse (HEK293, His)

    ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2

    Mouse HEK293
    ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-P134).
  • HY-P76141
    AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)

    5'-AMP-activated protein kinase; AMPK; AMPK (α1, β1, γ1) Protein

    Human Sf9 insect cells
    The AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), a crucial regulator of cellular energy metabolism. Activated by low ATP levels, it enhances energy production while suppressing biosynthetic processes and cell growth. The gamma subunit mediates AMP, ADP, and ATP binding, influencing AMPK activation or inhibition. Allosteric AMP binding activates the alpha subunit, while ADP stimulates phosphorylation, and ATP promotes dephosphorylation, rendering AMPK inactive. Additionally, AMPK modulates cellular polarity and interacts with FNIP1 and FNIP2. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~38 & 40 & 95 KDa, respectively.
  • HY-P76142
    AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)

    5'-AMP-activated protein kinase; AMPK; AMPK (α2, β1, γ1) Protein

    Human Sf9 insect cells
    The AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), a crucial regulator of cellular energy metabolism. Activated by low ATP levels, it enhances energy production while suppressing biosynthetic processes and cell growth. The gamma subunit mediates AMP, ADP, and ATP binding, influencing AMPK activation or inhibition. Allosteric AMP binding activates the alpha subunit, while ADP stimulates phosphorylation, and ATP promotes dephosphorylation, rendering AMPK inactive. Additionally, AMPK modulates cellular polarity and interacts with FNIP1 and FNIP2. AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 2 Heterotrimer protein, expressed by Sf9 insect cells, with N-His, N-GST, N-10*His labeled tag. AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~40 & 42 & 95 KDa, respectively.
  • HY-P76143
    AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)

    5'-AMP-activated protein kinase; AMPK; AMPK (α1, β2, γ1) Protein

    Human Sf9 insect cells
    The AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), a crucial regulator of cellular energy metabolism. Activated by low ATP levels, it enhances energy production while suppressing biosynthetic processes and cell growth. The gamma subunit mediates AMP, ADP, and ATP binding, influencing AMPK activation or inhibition. Allosteric AMP binding activates the alpha subunit, while ADP stimulates phosphorylation, and ATP promotes dephosphorylation, rendering AMPK inactive. Additionally, AMPK modulates cellular polarity and interacts with FNIP1 and FNIP2. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 2/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~35 & 37 & 95 KDa, respectively.
  • HY-P76176
    BMPRIB/ALK-6 Protein, Mouse (HEK293, Fc)

    Bone morphogenetic protein receptor type-1B; BMPR-1B; CDw293

    Mouse HEK293
    BMPR1B/ALK-6 protein is a type I member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPR1B/ALK-6 is the receptor for BMP-7/OP-1 and GDF-5, positively regulates chondrocyte differentiation through GDF-5 interaction. BMPR1B/ALK-6 also involves in SCUBE3/BMP-2/BMP-4 signals regulation, controlling growth, morphogenesis, and bone and teeth development. ALK-6/GDF-9/BMP-15 signals is essential in prolificacy of goat. The mouse BMPR1B/ALK-6 protein contains 502 amino acids and a transmembrane domain (127-148 a.a.). BMPRIB/ALK-6 Protein, Mouse (HEK293, Fc) is produced by HEK293 cells (K14-K126) with C-terminal hFc-tag.
  • HY-P70014
    CDK2 Protein, Human (His)

    rHuCyclin-dependent kinase 2/CDK2, His; Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; CDK2; CDKN2

    Human E. coli
    CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDK2 Protein, Human (His) is 298 a.a., with molecular weight of 32-35 kDa.
Cat. No. Product Name Effect Purity