1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. TGF-beta Superfamily Receptor Serine/Threonine Kinases Serine/Threonine Kinase Proteins
  4. Activin/Inhibins Receptor
  5. Activin A Receptor Type 2B (ACVR2B)

Activin A Receptor Type 2B (ACVR2B)

ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors[1].
The sequence of amino acids in ACVR2B proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ACVR2B has been only slightly altered, and that both in humans and in animals, its function is similar.
Activins and growth differentiation factors (GDF) bind to ACVR2B, which in turn activate type I receptors such as activin receptor-like kinases (ALK) ALK4 and ALK5, activating downstream molecule SMAD2/3. SMADSs regulate a number of myogenic genes, such as myoD, myogenin, and Myf5, that are involved in cellular hypertrophy, proliferation, or differentiation. Noncanonical ACVR2B pathways have also been shown to regulate MAP kinases. ACVR2B blocks signaling of myostatin, its close homolog GDF11, as well as activin A, activin B, and BMP10[1]. Activin A primarily binds to the type 1 receptors ALK4 or ALK7 in complex with ACVR2A or ACVR2B, causing activation of SMAD2 or SMAD3[2].
In myeloma cells, BMP-6- and BMP-9-induced activation of SMAD1/5/8 through ACVR2A/ACVR2B/ALK2 is inhibited by activin A treatment[2]. ACVR2B has been shown to preserve muscle mass and prolong survival in tumor hosts, and to increase bone mass in models of osteogenesis imperfecta and muscular dystrophy[3].

Cat. No. Product Name / Synonyms Species Source
  • HY-P72813
    ACVR2B Protein, Human (HEK293, Fc)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Human HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).
  • HY-P75535
    ACVR2B Protein, Mouse (HEK293, His-hFc)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Mouse HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His-hFc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 134 amino acids (M1-T134).
  • HY-P75536
    ACVR2B Protein, Mouse (HEK293, His)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Mouse HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-T134).
  • HY-P77290
    ACVR2B Protein, Cynomolgus (HEK293)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Cynomolgus HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293) is produced in HEK293 cells,and consists of 116 amino acids (S28-M143).
  • HY-P77291
    ACVR2B Protein, Cynomolgus (HEK293, Fc)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Cynomolgus HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 116 amino acids (S28-M143).
  • HY-P77292
    ACVR2B Protein, Cynomolgus (HEK293, His)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    Cynomolgus HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 116 amino acids (S28-M143).
  • HY-P7456
    ACVR2B Protein, Human (HEK293, His)

    rHuActivin receptor type 2B, His; ACVR-2B; Activin receptor type 2B

    Human HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 116 amino acids (S19-T134).
Cat. No. Product Name Effect Purity