2. Isotope-Labeled Compounds
  3. Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids

Nucleic acids, comprising of nucleobases, nucleosides, and nucleotides, are biopolymers, macromolecules, essential to all known forms of life. The two main classes of nucleic acids are deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ), both of which serve as the genetic information-carrying molecules. MedChemExpress ( MCE ) offers various Stable Isotope-Labeled nucleic acids and derivatives to assist protein structural analysis and DNA/RNA related researches.

Isotope-Labeled Nucleic Acids (126):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0617S
    S-Adenosyl-L-methionine-d3 68684-40-2 99.70%
    S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.
    S-Adenosyl-L-methionine-d<sub>3</sub>
  • HY-B0152S1
    Adenine-13C 86967-48-8 99.06%
    Adenine-13C is the 13C labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
    Adenine-<sup>13</sup>C
  • HY-F0004S
    Fosribnicotinamide-d4 99.55%
    Fosribnicotinamide-d4 (β-Nicotinamide mononucleotide-d4) is the deuterium labeled Fosribnicotinamide. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.
    Fosribnicotinamide-d<sub>4</sub>
  • HY-19528S
    SAH-d4 ≥99.0%
    SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM.
    SAH-d<sub>4</sub>
  • HY-16938S1
    5'-Methylthioadenosine-d3 174838-38-1 99.90%
    5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
    5'-Methylthioadenosine-d<sub>3</sub>
  • HY-N0091S7
    Hypoxanthine-15N4 77910-30-6 98.50%
    Hypoxanthine-15N4 is the 15N labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
    Hypoxanthine-<sup>15</sup>N<sub>4</sub>
  • HY-B1511S
    Cyclic AMP-13C5 2170095-23-3
    Cyclic AMP-13C5 is a deuterated cyclic AMP.
    Cyclic AMP-<sup>13</sup>C<sub>5</sub>
  • HY-D0184S2
    2'-Deoxycytidine-15N3 99.70%
    2'-Deoxycytidine-15N3 is the 15N labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
    2'-Deoxycytidine-<sup>15</sup>N<sub>3</sub>
  • HY-B0228S
    Adenosine-d 109923-50-4 99.97%
    Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-d
  • HY-I0960S1
    Uracil-13C4 99.88%
    Uracil-13C4 is the 13C labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil-<sup>13</sup>C<sub>4</sub>
  • HY-N1150S
    Thymidine-d3 74848-84-3 99.8%
    Thymidine-d3 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine-d<sub>3</sub>
  • HY-I0960S9
    Uracil-d4 24897-55-0 99.94%
    Uracil-d4 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d<sub>4</sub>
  • HY-150792S
    Inosine-15N4 204634-01-5 98.40%
    Inosine-15N4 is the 15N labeled Inosine.
    Inosine-<sup>15</sup>N<sub>4</sub>
  • HY-122524S
    7-Methylguanosine-d3 98.54%
    7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM.
    7-Methylguanosine-d<sub>3</sub>
  • HY-N0097S3
    Guanosine-15N5 204523-20-6 99.60%
    Guanosine-15N5 is the 15N labeled Guanosine. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
    Guanosine-<sup>15</sup>N<sub>5</sub>
  • HY-I0626S2
    Cytosine-d2 106391-24-6 99.69%
    Cytosine-d2 is the deuterium labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
    Cytosine-d<sub>2</sub>
  • HY-Y1055S
    Guanine-13C 201489-20-5 99.5%
    Guanine-13C is the 13C labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.
    Guanine-<sup>13</sup>C
  • HY-150770S
    Adenosine 5'-triphosphate(ATP)-d4 ammonium solution (100mM) 2483831-82-7
    Adenosine 5'-triphosphate(ATP)-d4 (ammonium salt) is the deuterium labeled Adenosine 5'-triphosphate(ATP) ammonium salt.
    Adenosine 5'-triphosphate(ATP)-d<sub>4</sub> ammonium solution (100mM)
  • HY-Y1055S1
    Guanine-13C,15N2 202407-12-3 98.6%
    Guanine-13C,15N2 is the 13C and 15N labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.
    Guanine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-90006S
    5-Fluorouracil-d1 90344-84-6 99.9%
    5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-d<sub>1</sub>