1. Isotope-Labeled Compounds
  2. Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids (39):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107372S
    Uridine triphosphate 13C9,15N2 sodium 285978-18-9 ≥98.0%
    Uridine triphosphate 13C9,15N2 (UTP 13C9,15N2) sodium is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
    Uridine triphosphate 13C9,15N2 sodium
  • HY-90006S2
    5-Fluorouracil-15N2 68941-95-7
    5-Fluorouracil-15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-15N2
  • HY-N0097S
    Guanosine-8-d 96412-41-8
    Guanosine-8-d is a deuterium labeled Guanosine. Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
    Guanosine-8-d
  • HY-17422S1
    Acyclovir-d4 1185179-33-2
    Acyclovir-d4 (Aciclovir-d4) is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.
    Acyclovir-d4
  • HY-N1150S1
    Thymidine-d4 347841-67-2
    Thymidine-d4 (DThyd-d4) is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine-d4
  • HY-N0092S
    Inosine-2,8-d2 697807-01-5
    Inosine-2,8-d2 is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
    Inosine-2,8-d2
  • HY-138615S
    Deoxythymidine-5'-triphosphate-13C10,15N2 disodium
    Deoxythymidine-5'-triphosphate-13C10,15N2 disodium is the 13C-labeled and 15N-labeled Deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate-13C10,15N2 disodium
  • HY-20710S
    2,6-Dichloro-9-isopropyl-9H-purine-d7
    2,6-Dichloro-9-isopropyl-9H-purine-d7
  • HY-132794S
    6-Ethyl Guanine-d5 183558-84-1
    6-Ethyl Guanine-d5
  • HY-113139S
    1-Methylinosine-d3
    1-Methylinosine-d3 (N1-Methylinosine-d3) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.
    1-Methylinosine-d3
  • HY-142636S
    Propylthiouracil-d5 sodium
    Propylthiouracil-d5 sodium
  • HY-B0228S
    Adenosine-d1 109923-50-4
    Adenosine-d1 (Adenine riboside-d1) is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-d1
  • HY-B1826S2
    Adefovir-d4 1190021-70-5
    Adefovir-d4 (GS-0393-d4) is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.
    Adefovir-d4
  • HY-19528S
    SAH-d4
    SAH-d4 (SAH (S-Adenosylhomocysteine)-d4) is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.
    SAH-d4
  • HY-B1743AS
    Puromycin-d3 dihydrochloride
    Puromycin-d3 (CL13900-d3) dihydrochloride is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis.
    Puromycin-d3 dihydrochloride
  • HY-17426S
    Famciclovir-d4 1020719-42-9
    Famciclovir-d4 (BRL 42810-d4) is the deuterium labeled Famciclovir. Famciclovir (BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.
    Famciclovir-d4
  • HY-W010450S
    Thymine-d4 200496-79-3
    Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine-d4
  • HY-17422S
    Acyclovir-d4 L-Leucinate 1795785-74-8
    Acyclovir-d4 L-Leucinate is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.
    Acyclovir-d4 L-Leucinate
  • HY-D0184S
    2'-Deoxycytidine-d1 25352-61-8
    2'-Deoxycytidine-d1 (Deoxycytidine-d1) is the deuterium labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
    2'-Deoxycytidine-d1
  • HY-107203S
    Propentofylline-d6 1216516-37-8
    Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia.
    Propentofylline-d6