2. Isotope-Labeled Compounds
  3. Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids

Nucleic acids, comprising of nucleobases, nucleosides, and nucleotides, are biopolymers, macromolecules, essential to all known forms of life. The two main classes of nucleic acids are deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ), both of which serve as the genetic information-carrying molecules. MedChemExpress ( MCE ) offers various Stable Isotope-Labeled nucleic acids and derivatives to assist protein structural analysis and DNA/RNA related researches.

Isotope-Labeled Nucleic Acids (111):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0617S
    S-Adenosyl-L-methionine-d3 68684-40-2 98.05%
    S-Adenosyl-L-methionine-d3 is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].
    S-Adenosyl-L-methionine-d<sub>3</sub>
  • HY-19528S
    SAH-d4 ≥98.0%
    SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
    SAH-d<sub>4</sub>
  • HY-B0152S
    Adenine-d 109923-52-6 ≥99.0%
    Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
    Adenine-d
  • HY-113139S
    1-Methylinosine-d3
    1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA[1].
    1-Methylinosine-d<sub>3</sub>
  • HY-122524S
    7-Methylguanosine-d3
    7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine[1]. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8?±?7.5?μM[2].
    7-Methylguanosine-d<sub>3</sub>
  • HY-150771S
    Uridine 5'-triphosphate (ammonium salt)-d8 2483831-69-0
    Uridine 5'-triphosphate (ammonium salt)-d8 is the deuterium labeled Uridine 5'-triphosphate ammonium salt[1].
    Uridine 5'-triphosphate (ammonium salt)-d<sub>8</sub>
  • HY-W008091S
    5-Methylcytosine-d4 1219795-15-9
    5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine[1]. 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development[2].
    5-Methylcytosine-d<sub>4</sub>
  • HY-F0004S
    β-Nicotinamide mononucleotide-d4
    β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
    β-Nicotinamide mononucleotide-d<sub>4</sub>
  • HY-B1743S
    Puromycin-d3
    Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
    Puromycin-d<sub>3</sub>
  • HY-13605S
    Cytarabine-d2 40632-26-6 ≥98.0%
    Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].
    Cytarabine-d<sub>2</sub>
  • HY-13677S1
    6-Mercaptopurine-13C2,15N 1190008-04-8
    6-Mercaptopurine-13C2,15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
    6-Mercaptopurine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-17426S
    Famciclovir-d4 1020719-42-9
    Famciclovir-d4 is the deuterium labeled Famciclovir. Famciclovir (BRL 42810) is a guanine analogue antiviral agent used for the treatment of various herpesvirus infections[1][2].
    Famciclovir-d<sub>4</sub>
  • HY-13677S
    6-Mercaptopurine-d2 82677-93-8
    6-Mercaptopurine-d2 is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent[1][2].
    6-Mercaptopurine-d<sub>2</sub>
  • HY-150709S
    Adenosine 5'-triphosphate-13C10,15N5 (ammonium)
    Adenosine 5'-triphosphate-13C10,15N5 (ammonium) is the 13C and 15N labeled Adenosine 5'-triphosphate ammonium[1].
    Adenosine 5'-triphosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> (ammonium)
  • HY-D0185S4
    2'-Deoxyguanosine-13C10,15N5 (monohydrate) 2483830-26-6
    2'-Deoxyguanosine-13C10,15N5 (monohydrate) is the 13C and 15N labeled 2'-Deoxyguanosine monohydrate[1]. 2'-Deoxyguanosine monohydrate is an endogenous metabolite.
    2'-Deoxyguanosine-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> (monohydrate)
  • HY-107372S
    Uridine triphosphate-13C9,15N2 (sodium) 285978-18-9
    Uridine triphosphate-13C9,15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
    Uridine triphosphate-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>2</sub> (sodium)
  • HY-150962S
    5-Hydroxycytosine-13C,15N2 181516-92-7
    5-Hydroxycytosine-13C,15N2 is the 13C and 15N labeled 5-Hydroxycytosine[1].
    5-Hydroxycytosine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-N6787S
    5,6-Dihydro-5-methyluracil-d6 334473-42-6
    5,6-Dihydro-5-methyluracil-d6 is the deuterium labeled 5,6-Dihydro-5-methyluracil. 5,6-Dihydro-5-methyluracil (Dihydrothymine), an intermediate breakdown product of thymine, comes from animal or plants. 5,6-Dihydro-5-methyluracil (Dihydrothymine) can be toxic when present at abnormally high levels[1].
    5,6-Dihydro-5-methyluracil-d<sub>6</sub>
  • HY-W012926S1
    Dihydrouracil-d4 334473-41-5
    Dihydrouracil-d4 is the deuterium labeled Dihydrouracil. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient.
    Dihydrouracil-d4
  • HY-90006S2
    5-Fluorouracil-15N2 68941-95-7 ≥99.0%
    5-Fluorouracil-15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].
    5-Fluorouracil-<sup>15</sup>N<sub>2</sub>