1. Protein Tyrosine Kinase/RTK
  2. FGFR

FGFR

FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins. Some of these receptors are involved in pathological conditions. A point mutation in FGFR3 can lead to achondroplasia. Five distinct membrane FGFR have been identified in vertebrates and all of them belong to the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). The fibroblast growth factor family constitutes one of the most important groups of paracrine factors that act during development. They are responsible for determining certain cells to become mesoderm, for the production of blood vessels, for limb outgrowth, and for the growth and differentiation of numerous cell types.

FGFR Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-50904
    BIBF 1120 Inhibitor
    BIBF 1120 is a potent triple angiokinase inhibitor for VEGFR1/2/3FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
  • HY-12047
    Ponatinib Inhibitor
    Ponatinib is a potent, orally available multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
  • HY-13330
    AZD4547 Inhibitor
    AZD4547 is a potent inhibitor of the FGFR family with IC50 of 0.2 nM, 2.5 nM, 1.8 nM, and 165 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
  • HY-13311
    NVP-BGJ398 Inhibitor
    NVP-BGJ398 is a potent inhibitor of the FGFR family with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
  • HY-10321
    PD173074 Inhibitor
    PD173074 is a potent FGFR1 inhibitor with IC50 of 25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, 1000-fold selective for FGFR1 than PDGFR and c-Src.
  • HY-10207
    Dovitinib lactate Inhibitor
    Dovitinib(CHIR-258; TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) with an IC50 of 5 nM.
  • HY-12965
    S49076 Inhibitor
    S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.
  • HY-100492
    BLU-554 Inhibitor
    BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.
  • HY-18708
    Erdafitinib Inhibitor
    Erdafitinib is a quinoxaline derivative compound, acts on FGFR1/2/3/4 with mean pIC50 of ~ 9/8.5/8.5/8.25, respectively.
  • HY-10407
    SU 5402 Inhibitor
    SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively.
  • HY-12823
    BLU9931 Inhibitor
    BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.
  • HY-13304
    LY2874455 Inhibitor
    LY2874455 is a pan-FGFR inhibitor with a similar potency for each enzyme. LY2874455 inhibits FGFR1, 2, 3, and 4 with IC50s of 2.8, 2.6, 6.4, and 6 nM, respectively.
  • HY-15391
    E-3810 Inhibitor
    E-3810 is a novel dual inhibitor of the VEGF and FGF receptors, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50 of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.
  • HY-12009
    Pazopanib Hydrochloride Inhibitor
    Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
  • HY-13034
    LY2784544 Inhibitor
    LY2784544 is a potent JAK2 inhibitor with IC50 of 3 nM. LY2784544 also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM.
  • HY-11106
    BIBF 1120 esylate Inhibitor
    Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM.
  • HY-15599
    SSR128129E Inhibitor
    SSR128129E is a multi-FGFR blocker with allosteric properties; inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding.
  • HY-18602
    FIIN-2 Inhibitor
    FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.
  • HY-19957
    CH5183284 Inhibitor
    CH5183284 is a selective and orally available FGFR1/2/3 inhibitor. The IC50 values of CH5183284 on the enzyme activity of FGFR1/2/3/4 were 9.3, 7.6, 22, and 290 nM, respectively.
  • HY-15992
    BIBF 1202 Inhibitor
    BIBF 1202 is the carboxylate metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR.