1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR1 Inhibitors

FGFR1 Inhibitors

FGFR

FGFR1

FGFR2

FGFR3

FGFR4

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Sorry. There is currently no product that acts on isoform FGFR1 together.

Please try each isoform separately.

FGFR1 Specific Inhibitors
Product Name FGFR1 FGFR2 FGFR3 FGFR4 FGFR1 Selectivity Purity
SU 5402
FGFR1, IC50: 30 nM
      Selective Inhibitor 99.39%
KW-2449
FGFR1, IC50: 36 nM
      Selective Inhibitor 99.85%
Pazopanib Hydrochloride
FGFR1, IC50: 140 nM
      Selective Inhibitor 99.84%
PD-166866
FGFR1, IC50: 52.4 nM
      Selective Inhibitor 99.97%
Orantinib
FGFR1, Ki: 1.2 μM
      Selective Inhibitor 98.80%
Tyrosine kinase-IN-1
FGFR1, IC50: 2 nM
      Selective Inhibitor 99.47%
FGFR1/DDR2 inhibitor 1
FGFR1, IC50: 31.1 nM
      Selective Inhibitor 99.03%
SU4984
FGFR1, IC50: 10-20 μM
      Selective Inhibitor
Lenvatinib
FGFR1, IC50: 46 nM
      Pan Inhibitor 99.87%
Nintedanib
FGFR1, IC50: 69 nM
FGFR2, IC50: 37 nM
FGFR3, IC50: 108 nM
  Pan Inhibitor 99.97%
Erdafitinib
FGFR1, IC50: 1.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 3.0 nM
FGFR4, IC50: 5.7 nM
Pan Inhibitor 99.66%
Ponatinib
FGFR1, IC50: 2.2 nM
      Pan Inhibitor 99.13%
Infigratinib
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
Pan Inhibitor 99.55%
Dovitinib lactate hydrate
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
  Pan Inhibitor
E7090
FGFR1, IC50: 0.71 nM
FGFR2, IC50: 0.50 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 120 nM
Pan Inhibitor
E7090 succinate
FGFR1, IC50: 0.71 nM
FGFR2, IC50: 0.50 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 120 nM
Pan Inhibitor
AZD4547
FGFR1, IC50: 0.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 1.8 nM
FGFR4, IC50: 165 nM
Pan Inhibitor 99.68%
Pemigatinib
FGFR1, IC50: 0.4 nM
FGFR2, IC50: 0.5 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 30 nM
Pan Inhibitor 99.88%
Pazopanib
FGFR1, IC50: 140 nM
      Pan Inhibitor 99.68%
PD173074
FGFR1, IC50: 25 nM
      Pan Inhibitor 99.67%
Futibatinib
FGFR1, IC50: 3.9 nM
FGFR2, IC50: 1.3 nM
wild-type FGFR2, IC50: 0.3 nM
FGFR2 V5651, IC50: 1-3 nM
FGFR2 N550H, IC50: 3.6 nM
FGFR2 E566G, IC50: 2.4 nM
FGFR3, IC50: 1.6 nM
FGFR4, IC50: 8.3 nM
Pan Inhibitor 98.80%
Nintedanib esylate
FGFR1, IC50: 69 nM
FGFR2, IC50: 37 nM
FGFR3, IC50: 108 nM
  Pan Inhibitor 99.93%
Dovitinib
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
  Pan Inhibitor 99.94%
Roblitinib
FGFR1, IC50: >10 μM
FGFR2, IC50: >10 μM
FGFR3, IC50: >10 μM
FGFR4, IC50: 1.9 nM
rat FGFR4, IC50: >10 μM
Pan Inhibitor ≥98.0%
LY2874455
FGFR1, IC50: 2.8 nM
FGFR2, IC50: 2.6 nM
FGFR3, IC50: 6.4 nM
FGFR4, IC50: 6 nM
Pan Inhibitor 98.06%
BLU9931
FGFR1, IC50: 591 nM
FGFR2, IC50: 493 nM
FGFR3, IC50: 150 nM
FGFR4, IC50: 3 nM
Pan Inhibitor ≥98.0%
Lucitanib
FGFR1, IC50: 17.5 nM
FGFR2, IC50: 82.5 nM
    Pan Inhibitor 99.32%
Ferulic acid
FGFR1, IC50: 3.78 μM
FGFR2, IC50: 12.5 μM
    Pan Inhibitor 99.87%
CH5183284
FGFR1, IC50: 9.3 nM
FGFR2, IC50: 7.6 nM
FGFR3, IC50: 22 nM
FGFR4, IC50: 290 nM
Pan Inhibitor 99.73%
ENMD-2076
FGFR1, IC50: 92.7 nM
FGFR2, IC50: 70.8 nM
    Pan Inhibitor 99.12%
Lenvatinib mesylate
FGFR1, IC50: 46 nM
      Pan Inhibitor 99.86%
PRN1371
FGFR1, IC50: 0.6 nM
FGFR2, IC50: 1.3 nM
FGFR3, IC50: 4.1 nM
FGFR4, IC50: 19.3 nM
Pan Inhibitor 99.72%
Derazantinib
FGFR1, IC50: 4.5 nM
FGFR2, IC50: 1.8 nM
FGFR3, IC50: 4.5 nM
  Pan Inhibitor 99.18%
TG 100801
FGFR1, IC50: 2 nM
FGFR2, IC50: 16 nM
    Pan Inhibitor ≥95.0%
Dovitinib lactate
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
  Pan Inhibitor 99.96%
ODM-203
FGFR1, IC50: 11 nM
FGFR2, IC50: 16 nM
FGFR3, IC50: 6 nM
FGFR4, IC50: 35 nM
Pan Inhibitor 99.33%
S49076
FGFR1, IC50: 18 nM
FGFR1V561M, IC50: 23 nM
FGFR2, IC50: 17 nM
FGFR2N549H, IC50: 19 nM
FGFR3, IC50: 15 nM
  Pan Inhibitor 98.62%
FIIN-2
FGFR1, IC50: 3.1 nM
FGFR2, IC50: 4.3 nM
FGFR3, IC50: 27 nM
FGFR4, IC50: 45 nM
Pan Inhibitor 99.95%
ASP5878
FGFR1, IC50: 0.47 nM
FGFR2, IC50: 0.6 nM
FGFR3, IC50: 0.74 nM
FGFR4, IC50: 3.5 nM
Pan Inhibitor 99.71%
R1530
FGFR1, IC50: 28 nM
      Pan Inhibitor 99.06%
ENMD-2076 Tartrate
FGFR1, IC50: 92.7 nM
FGFR2, IC50: 70.8 nM
    Pan Inhibitor 98.87%
EOC317
FGFR1, IC50: 6 nM
      Pan Inhibitor 98.11%
SSR128129E
FGFR1, IC50: 1.9 μM
      Pan Inhibitor 99.86%
FIIN-3
FGFR1, IC50: 13.1 nM
FGFR2, IC50: 21 nM
FGFR3, IC50: 31.4 nM
FGFR4, IC50: 35.3 nM
Pan Inhibitor 98.13%
Infigratinib phosphate
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
Pan Inhibitor 97.74%
PD-161570
FGFR1, IC50: 39.9 nM
FGFR1, Ki: 42 nM
FGFR1 autophosphorylation, IC50: 622 nM
      Pan Inhibitor 99.04%
(Z)-Orantinib
FGFR1, IC50: 1.2 μM
      Pan Inhibitor 99.02%
TG 100572
FGFR1, IC50: 2 nM
FGFR2, IC50: 16 nM
    Pan Inhibitor
CPL304110
FGFR1, IC50: 0.75 nM
FGFR2, IC50: 0.5 nM
FGFR3, IC50: 3.05 nM
  Pan Inhibitor
ARQ 069
unphosphorylated FGFR1, IC50: 0.84 μM
FGFR1 autophosphorylation, IC50: 2.8 μM
unphosphorylated FGFR2, IC50: 1.23 μM
FGFR2 autophosphorylation, IC50: 1.9 μM
    Pan Inhibitor
PD-089828
FGFR1, IC50: 0.15 μM
FGFR1, Ki: 0.14 μM
      Pan Inhibitor
FIIN-1
FGFR1, Kd: 2.8 nM
FGFR1, IC50: 9.2 nM
FGFR2, Kd: 6.9 nM
FGFR2, IC50: 6.2 nM
FGFR3, Kd: 5.4 nM
FGFR3, IC50: 11.9 nM
FGFR4, Kd: 120 nM
FGFR4, IC50: 189 nM
Pan Inhibitor
Ponatinib D8
FGFR1, IC50: 2.2 nM
      Pan Inhibitor
TG 100801 Hydrochloride
FGFR1, IC50: 2 nM
FGFR2, IC50: 16 nM
    Pan Inhibitor
SSR128129E free acid
FGFR1, IC50: 1.9 μM
      Pan Inhibitor
Rogaratinib
FGFR1
FGFR2
FGFR3
FGFR4
Inhibitor 99.86%
Sulfatinib
FGFR1
      Inhibitor 98.01%