1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR1 Inhibitors

FGFR1 Inhibitors

FGFR

FGFR1

FGFR2

FGFR3

FGFR4

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Sorry. There is currently no product that acts on isoform FGFR1 together.

Please try each isoform separately.

FGFR1 Specific Inhibitors
Product Name FGFR1 FGFR2 FGFR3 FGFR4 FGFR1 Selectivity Purity
SU 5402
FGFR1, IC50: 30 nM
      Selective Inhibitor 99.39%
KW-2449
FGFR1, IC50: 36 nM
      Selective Inhibitor 99.85%
Pazopanib Hydrochloride
FGFR1, IC50: 140 nM
      Selective Inhibitor 99.83%
PD-166866
FGFR1, IC50: 52.4 nM
      Selective Inhibitor 99.97%
Orantinib
FGFR1, Ki: 1.2 μM
      Selective Inhibitor 98.80%
Tyrosine kinase-IN-1
FGFR1, IC50: 2 nM
      Selective Inhibitor 99.47%
Lenvatinib
FGFR1, IC50: 46 nM
      Pan Inhibitor 99.74%
Nintedanib
FGFR1, IC50: 69 nM
FGFR2, IC50: 37 nM
FGFR3, IC50: 108 nM
  Pan Inhibitor 99.85%
Ponatinib
FGFR1, IC50: 2.2 nM
      Pan Inhibitor 99.13%
Infigratinib
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
Pan Inhibitor 99.16%
AZD4547
FGFR1, IC50: 0.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 1.8 nM
FGFR4, IC50: 165 nM
Pan Inhibitor 99.80%
Ponatinib D8
FGFR1, IC50: 2.2 nM
      Pan Inhibitor
PD173074
FGFR1, IC50: 25 nM
      Pan Inhibitor 99.55%
Pemigatinib
FGFR1, IC50: 0.4 nM
FGFR2, IC50: 0.5 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 30 nM
Pan Inhibitor 98.95%
Nintedanib esylate
FGFR1, IC50: 69 nM
FGFR2, IC50: 37 nM
FGFR3, IC50: 108 nM
  Pan Inhibitor 99.95%
Lucitanib
FGFR1, IC50: 17.5 nM
FGFR2, IC50: 82.5 nM
    Pan Inhibitor 99.32%
LY2874455
FGFR1, IC50: 2.8 nM
FGFR2, IC50: 2.6 nM
FGFR3, IC50: 6.4 nM
FGFR4, IC50: 6 nM
Pan Inhibitor 98.02%
Dovitinib
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
  Pan Inhibitor 97.18%
PRN1371
FGFR1, IC50: 0.6 nM
FGFR2, IC50: 1.3 nM
FGFR3, IC50: 4.1 nM
FGFR4, IC50: 19.3 nM
Pan Inhibitor 99.72%
BLU9931
FGFR1, IC50: 591 nM
FGFR2, IC50: 493 nM
FGFR3, IC50: 150 nM
FGFR4, IC50: 3 nM
Pan Inhibitor 99.77%
CH5183284
FGFR1, IC50: 9.3 nM
FGFR2, IC50: 7.6 nM
FGFR3, IC50: 22 nM
FGFR4, IC50: 290 nM
Pan Inhibitor 99.73%
Derazantinib
FGFR1, IC50: 4.5 nM
FGFR2, IC50: 1.8 nM
FGFR3, IC50: 4.5 nM
  Pan Inhibitor 99.06%
ENMD-2076
FGFR1, IC50: 92.7 nM
FGFR2, IC50: 70.8 nM
    Pan Inhibitor 99.23%
FIIN-2
FGFR1, IC50: 3.1 nM
FGFR2, IC50: 4.3 nM
FGFR3, IC50: 27 nM
FGFR4, IC50: 45 nM
Pan Inhibitor 99.95%
ENMD-2076 Tartrate
FGFR1, IC50: 92.7 nM
FGFR2, IC50: 70.8 nM
    Pan Inhibitor 98.59%
S49076
FGFR1, IC50: 18 nM
FGFR1V561M, IC50: 23 nM
FGFR2, IC50: 17 nM
FGFR2N549H, IC50: 19 nM
FGFR3, IC50: 15 nM
  Pan Inhibitor 98.62%
EOC317
FGFR1, IC50: 6 nM
      Pan Inhibitor 97.65%
SSR128129E
FGFR1, IC50: 1.9 μM
      Pan Inhibitor 99.65%
ASP5878
FGFR1, IC50: 0.47 nM
FGFR2, IC50: 0.6 nM
FGFR3, IC50: 0.74 nM
FGFR4, IC50: 3.5 nM
Pan Inhibitor 99.71%
FIIN-3
FGFR1, IC50: 13.1 nM
FGFR2, IC50: 21 nM
FGFR3, IC50: 31.4 nM
FGFR4, IC50: 35.3 nM
Pan Inhibitor 98.13%
Infigratinib phosphate
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
Pan Inhibitor 97.74%
Lenvatinib mesylate
FGFR1, IC50: 46 nM
      Pan Inhibitor
ODM-203
FGFR1, IC50: 11 nM
FGFR2, IC50: 16 nM
FGFR3, IC50: 6 nM
FGFR4, IC50: 35 nM
Pan Inhibitor 99.15%
SSR128129E free acid
FGFR1, IC50: 1.9 μM
      Pan Inhibitor
Rogaratinib
FGFR1
FGFR2
FGFR3
FGFR4
default Inhibitor 99.38%
Sulfatinib
FGFR1
      default Inhibitor 97.97%
SKLB610
FGFR1
      default Inhibitor 99.23%