SMAD2
SMAD2 is the R-SMAD dedicated to TGF-β/activin/nodal signaling, activated by TGFBR1 (ALK5), ALK4 and ALK7 through C-terminal phosphorylation, after which it heterotrimerizes with SMAD4 and accumulates in the nucleus to regulate transcription. SMAD2 is unique among R-SMADs: its MH1 domain contains an extra insert that abolishes direct DNA binding, so it tethers to DNA only via SMAD4 and partner transcription factors such as FOXH1 (in embryonic development) and SMAD3-dependent complexes. During embryogenesis SMAD2-Nodal signaling specifies anterior-posterior patterning, mesendoderm induction and left-right asymmetry-Smad2 knockout mice fail at gastrulation. In differentiated cells, SMAD2 mediates TGF-β-driven cytostatic (p15, p21 induction, c-MYC repression) and immunosuppressive gene programs. SMAD2 is seldom mutated in cancer; instead, loss of SMAD2 activity typically reflects upstream receptor or SMAD4 inactivation, whereas SMAD2 activation supports carcinoma invasiveness, epithelial-mesenchymal transition and fibrotic progression.
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SMAD2 Recombinant Proteins (2)
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Inhibitors & Agonists (303)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
