Procollagen C Proteinase
Procollagen C proteinase (PCP) and its enhancer protein (PCPE) are key to collagen fibril-assembly and extracellular matrix formation. PCP cleaves the carboxyl-propeptides of procollagens types I, II, and III and this initiates the self-assembly of collagen fibrils. PCP can also process pro-lysyl oxidase and laminin 5, and it may cleave the type V procollagen N-propeptides. Procollagen processing by PCP is stimulated by PCPE, a glycoprotein that binds to the C-propeptide of type I procollagen through its N-terminal CUB domains. PCP/BMP-1 related proteases can activate TGF-β-like growth factors. PCPs have important biological functions in addition to their role in collagen fibril assembly.
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Procollagen C Proteinase Related Products (2)
Related Products (2)
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UK-383367
0 ImagesUK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring.
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Acetyltetrapeptide 11
0 ImagesCat. No.: HY-P5233CAS No.: 928006-88-6Acetyltetrapeptide 11 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
