348622-88-8
348622-88-8
Chemical Structure
UK-383367
- CAS No.: 348622-88-8
- Formula:C15H24N4O4
- Molecular Weight:324.38
IUPAC Name: (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
InChIKey: ARJCBSRIPGJMAD-LLVKDONJSA-N
SMILES: NC(C1=NOC([C@H](CCCC2CCCCC2)CC(NO)=O)=N1)=O
Biological Activity: UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UK-383367 | 99.95% | UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring. | ||||||||||||||||||||
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References
- [1]. Mi Bai, et al. BMP1 inhibitor UK383,367 attenuates renal fibrosis and inflammation in CKD. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1430-F1438. [Content Brief]
- [2]. Allan GA, et al. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica. 2006 May;36(5):399-418. [Content Brief]
- [3]. Eugenia C Salcedo, et al. Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer. ACS Chem Biol. 2021 Apr 16;16(4):712-723. [Content Brief]
