1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Itk

Itk

Itk (Interleukin-2-inducible T-cell kinase) is a member of the TEC family of kinases and is highly expressed in T cells. Itk plays a role in T-cell proliferation, differentiation, cytokine release and chemotaxis. Itk is functionally important for the development and effector function of Th2 and Th17 cells. Itk is an attractive target for the treatment of T-cell-mediated inflammatory diseases.

Itk Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-11092
    BMS-509744 Inhibitor 98.02%
    BMS-509744 is a potent, selective and ATP competitive Itk inhibitor with an IC50 of 19 nM.
  • HY-12680
    PRN694 Inhibitor 99.44%
    PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo.
  • HY-109078
    Vecabrutinib Inhibitor 99.96%
    Vecabrutinib is a potent, noncovalent BTK and ITK inhibitor, with Kd of 0.3 nM and 2.2 nM, respectively; Vecabrutinib shows an IC50 of 24 nM for ITK.
  • HY-11066
    ITK inhibitor Inhibitor
    ITK inhibitor is a potent ITK inhibitor.
  • HY-16984
    GNE-4997 Inhibitor
    GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity.
  • HY-128726
    ITK inhibitor 2 Inhibitor
    ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2 nM.
  • HY-108691
    PF-06465469 Inhibitor
    PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM.
Isoform Specific Products

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