1. Protein Tyrosine Kinase/RTK
  2. Itk


Itk (Interleukin-2-inducible T-cell kinase) is a member of the TEC family of kinases and is highly expressed in T cells. Itk plays a role in T-cell proliferation, differentiation, cytokine release and chemotaxis. Itk is functionally important for the development and effector function of Th2 and Th17 cells. Itk is an attractive target for the treatment of T-cell-mediated inflammatory diseases.

Itk Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-11092
    BMS-509744 Inhibitor 98.02%
    BMS-509744 is a potent and selective Itk kinase inhibitor with an IC50 value of 19 nM.
  • HY-101941
    SNS-062 Inhibitor 98.88%
    SNS-062 is a potent, noncovalent BTK and ITK inhibitor, with Kd of 0.3 nM and 2.2 nM, respectively; SNS-062 shows an IC50 of 24 nM for ITK.
  • HY-12680
    PRN694 Inhibitor 99.44%
    PRN694 is a highly selective and potent covalent inhibitor of T cell kinase (ITK) and resting lymphocyte kinase (RLK) with IC50s of 0.3 and 1.4 nM, respectively.
  • HY-11066
    ITK inhibitor Inhibitor
    ITK inhibitor is a potent ITK inhibitor.
Isoform Specific Products

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