2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Itk
  5. Itk Degrader

Itk Degrader

Itk Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-149917
    ITK degrader 1
    		Degrader
    ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice). ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 also shows good plasma exposure levels.
  • HY-153322
    ITK degrader 2
    		Degrader
    ITK degrader 2 (compound 30) is a modulator of targeted ubiquitination and a targeted protein degrading molecule. ITK degrader 2 degrades ITK.