2858738-65-3
Chemical Structure
ITK degrader 2
- CAS No.: 2858738-65-3
- Formula:C41H49F2N9O3
- Molecular Weight:753.88
IUPAC Name: (2S)-N-(2-((4aS,5aR)-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazol-3-yl)-1H-indol-6-yl)-2-(4-((1-(5-(2,6-dioxopiperidin-3-yl)pyridin-2-yl)piperidin-4-yl)methyl)piperazin-1-yl)-N-methylpropanamide
InChIKey: IARVPXVRJRSDRO-KONCDOQBSA-N
SMILES: C[C@@]12[C@@](CC3=C(NN=C3C(NC4=C5)=CC4=CC=C5N(C)C([C@@H](N6CCN(CC6)CC7CCN(C8=CC=C(C9C(NC(CC9)=O)=O)C=N8)CC7)C)=O)C2)([H])C1(F)F
Biological Activity: ITK degrader 2 is an orally active ITK PROTAC degrader with a DC50 < 0.001 nM. ITK degrader 2 degrades ITK via the ubiquitin-proteasome pathway. ITK degrader 2 can be used in the research of cancer, autoimmune diseases and inflammatory diseases[1].
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ITK degrader 2 | ITK degrader 2 is an orally active ITK PROTAC degrader with a DC50 < 0.001 nM. ITK degrader 2 degrades ITK via the ubiquitin-proteasome pathway. ITK degrader 2 can be used in the research of cancer, autoimmune diseases and inflammatory diseases. | |||||||||||||||||||||
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