1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Cytoskeleton
  3. Kinesin

Kinesin

Kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo. Most kinesins walk towards the plus end of a microtubule, entails transporting cargo from the centre of the cell towards the periphery. Kinesins were discovered as microtubule (MT)-based anterograde intracellular transport motors. The founding member of this superfamily, the genomes of mammals encode more than 40 kinesin proteins, organized into at least 14 families named kinesin-1 through kinesin-14.

Kinesin Isoform Specific Products:

  • Kinesin-5/Eg5/KSP

  • Kinesin-6

  • Kinesin-7/CENP-E

  • Kinesin-12

  • Kinesin-14

Kinesin Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-15187
    Filanesib Inhibitor 99.73%
    Filanesib (ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
  • HY-10299
    GSK-923295 Inhibitor >99.0%
    GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.
  • HY-50759
    Ispinesib Inhibitor 98.71%
    Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
  • HY-15948
    Kif15-IN-1 Inhibitor 99.04%
    Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.
  • HY-101071A
    Monastrol Inhibitor 99.89%
    Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
  • HY-14846
    Litronesib Inhibitor 99.59%
    Litronesib is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.
  • HY-15857
    CW-069 Inhibitor 99.75%
    CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC50 of 75 μM.
  • HY-12069
    SB-743921 Inhibitor
    SB-743921 is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
  • HY-15949
    Kif15-IN-2 Inhibitor
    Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
  • HY-19530
    PF-2771 Inhibitor >99.0%
    PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent.
  • HY-12241
    AZ82 Inhibitor 99.08%
    AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
  • HY-19966
    K858 Racemic Inhibitor 99.93%
    K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
  • HY-19944
    Dimethylenastron Inhibitor 98.24%
    Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC50 of 200 nM.
  • HY-101298
    Paprotrain Inhibitor
    Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
  • HY-15000
    EMD534085 Inhibitor 98.61%
    EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
  • HY-112915
    Eg5 Inhibitor V, trans-24 Inhibitor
    Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer.
  • HY-15187A
    (R)-Filanesib Inhibitor 98.86%
    (R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of ARRY-520. (R)-Filanesib ((R)-ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
  • HY-14846A
    Litronesib Racemate 99.00%
    Litronesib (Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.