Signaling Pathway

Kinesin

Kinesin

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Kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo. Most kinesins walk towards the plus end of a microtubule, entails transporting cargo from the centre of the cell towards the periphery. Kinesins were discovered as microtubule (MT)-based anterograde intracellular transport motors. The founding member of this superfamily, the genomes of mammals encode more than 40 kinesin proteins, organized into at least 14 families named kinesin-1 through kinesin-14.

Kinesin Inhibitors & Modulators (10)

Product Name Catalog No. Brief Description
CW-069

HY-15857

CW-069  is a novel and allosteric inhibitor of the microtubule motor protein HSET with IC50 value of 75 ± 20 μM; shows statistically significant selectivity over KSP.

EMD534085

HY-15000

EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.

GSK-923295

HY-10299

GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183.

HMN-176

HY-13647

HMN-176 is a stilbene derivative which inhibits mitosis without significant effect on tubulin polymerization.

Kif15-IN-1

HY-15948

Kif15-IN-1 is a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in tumor cell lines.

Kif15-IN-2

HY-15949

Kif15-IN-2 is a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in tumor cell lines.

Monastrol

HY-101071A

Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.

MPI-0479605

HY-12660

MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.

PF-2771

HY-19530

PF-2771 is a potent, selective CENP-E inhibitor, PF-2771 inhibits CENP-E motor activity with an IC50 of 16.1 ± 1.2 nM.

Rbin-1

HY-100816

Rbin-1 is a potent, reversible, and specific inhibitor of eukaryotic ribosome biogenesis.