1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. mTOR
  4. mTORC1 Inhibitors

mTORC1 Inhibitors

mTOR

mTORC1

mTORC2

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Sorry. There is currently no product that acts on isoform mTORC1 together.

Please try each isoform separately.

mTORC1 Specific Inhibitors & Activators
Product Name mTORC1 mTOR mTORC2 mTORC1 Selectivity Purity
Rapamycin
mTOR, IC50: 0.1 nM (in HEK293 cells )
    Selective Inhibitor 99.93%
Everolimus
mTOR, IC50: 5-6 nM
    Selective Inhibitor 98.79%
Temsirolimus
mTOR, IC50: 1.76 μM
    Selective Inhibitor 99.56%
Deforolimus
mTOR
    Selective Inhibitor 98.46%
L-Leucine
mTORC1
    Selective Activator >98.0%
MHY1485
mTORC1
 
mTORC2
Pan Activator 99.05%
Torkinib
mTORC1, IC50: 30 nM
mTOR, IC50: 8 nM
mTORC2, IC50: 58 nM
Pan Inhibitor 97.75%
PI-103
mTORC1, IC50: 20 nM
 
mTORC2, IC50: 83 nM
Pan Inhibitor 99.86%
Omipalisib
mTORC1, Ki: 0.18 nM
 
mTORC2, Ki: 0.3 nM
Pan Inhibitor 99.31%
OSI-027
mTORC1, IC50: 22 nM
mTOR, IC50: 4 nM
mTORC2, IC50: 65 nM
Pan Inhibitor 99.40%
Dihydromyricetin
mTORC1
 
mTORC2
Pan Inhibitor 99.54%
PI-103 Hydrochloride
mTORC1, IC50: 20 nM
 
mTORC2, IC50: 83 nM
Pan Inhibitor 99.78%
Voxtalisib
mTORC1, IC50: 160 nM
mTOR, IC50: 157 nM
mTORC2, IC50: 910 nM
Pan Inhibitor 98.93%
PQR620
mTORC1
 
mTORC2
Pan Inhibitor 98.06%
PQR-530
mTORC1
 
mTORC2
Pan Inhibitor
Palomid 529
TORC1
 
TORC2
Pan Inhibitor 99.44%
(+)-Usnic acid
mTORC1
 
mTORC2
Pan Inhibitor 99.21%
FT-1518
mTORC1
 
mTORC2
Pan Inhibitor