1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. mTOR
  4. mTORC1 Inhibitors

mTORC1 Inhibitors

mTOR

mTORC1

mTORC2

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Sorry. There is currently no product that acts on isoform mTORC1 together.

Please try each isoform separately.

mTORC1 Specific Inhibitors & Activators
Product Name mTORC1 mTOR mTORC2 mTORC1 Selectivity Purity
Rapamycin
mTOR, IC50: 0.1 nM (in HEK293 cells )
    Selective Inhibitor 99.94%
Everolimus
mTOR, IC50: 5-6 nM
    Selective Inhibitor 99.10%
Temsirolimus
mTOR, IC50: 1.76 μM
    Selective Inhibitor 99.56%
L-Leucine
mTORC1
    Selective Activator >98.0%
Ridaforolimus
mTOR
    Selective Inhibitor >98.0%
MT 63-78
mTORC1
    Selective Inhibitor
Torin 1
mTORC1, IC50: 2-10 nM
mTOR, IC50: 3 nM
mTORC2, IC50: 2-10 nM
Pan Inhibitor >99.0%
MHY1485
mTORC1
 
mTORC2
Pan Activator 99.86%
PI-103
mTORC1, IC50: 20 nM
 
mTORC2, IC50: 83 nM
Pan Inhibitor 99.86%
Torkinib
mTORC1, IC50: 30 nM
mTOR, IC50: 8 nM
mTORC2, IC50: 58 nM
Pan Inhibitor 98.76%
Omipalisib
mTORC1, Ki: 0.18 nM
 
mTORC2, Ki: 0.3 nM
Pan Inhibitor 99.31%
OSI-027
mTORC1, IC50: 22 nM
mTOR, IC50: 4 nM
mTORC2, IC50: 65 nM
Pan Inhibitor 99.40%
Dihydromyricetin
mTORC1
 
mTORC2
Pan Inhibitor 99.79%
Voxtalisib
mTORC1, IC50: 160 nM
mTOR, IC50: 157 nM
mTORC2, IC50: 910 nM
Pan Inhibitor 99.46%
PQR620
mTORC1
 
mTORC2
Pan Inhibitor 98.06%
PI-103 Hydrochloride
mTORC1, IC50: 20 nM
 
mTORC2, IC50: 83 nM
Pan Inhibitor 98.06%
Palomid 529
TORC1
 
TORC2
Pan Inhibitor 99.47%
(+)-Usnic acid
mTORC1
 
mTORC2
Pan Inhibitor >99.0%