1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. mTOR
  4. mTORC1 Isoform

mTORC1

 

mTORC1 Related Products (47):

Cat. No. Product Name Effect Purity
  • HY-10219
    Rapamycin
    Inhibitor 99.94%
    Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells.
  • HY-10218
    Everolimus
    Inhibitor 99.74%
    Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor.
  • HY-B0795
    MHY1485
    Activator 99.86%
    MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR.
  • HY-13003
    Torin 1
    Inhibitor 98.95%
    Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM.
  • HY-10422
    AZD-8055
    Inhibitor 99.60%
    AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
  • HY-N3628
    Coronarin A
    Inhibitor
    Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity.
  • HY-12652
    AZD3147
    Inhibitor
    AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM.
  • HY-50673
    Dactolisib
    Inhibitor 99.94%
    Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC50s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively.
  • HY-13328
    Sapanisertib
    Inhibitor 99.66%
    Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.
  • HY-50910
    Temsirolimus
    Inhibitor 99.56%
    Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM.
  • HY-13002
    Torin 2
    Inhibitor 99.98%
    Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM).
  • HY-10474
    Torkinib
    Inhibitor 98.37%
    Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM.
  • HY-N0486
    L-Leucine
    Activator 99.79%
    L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
  • HY-10297
    Omipalisib
    Inhibitor 99.93%
    Omipalisib (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
  • HY-15247
    Vistusertib
    Inhibitor 98.21%
    Vistusertib (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM.
  • HY-10115
    PI-103
    Inhibitor 98.93%
    PI-103 is a potent PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2.
  • HY-N0112
    Dihydromyricetin
    Inhibitor 98.10%
    Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase.
  • HY-12513
    Samotolisib
    Inhibitor 99.42%
    Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively.
  • HY-50710
    KU-0063794
    Inhibitor 99.55%
    KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC50s of 10 nM.
  • HY-15174
    Dactolisib Tosylate
    Inhibitor 99.88%
    Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively.