1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kγ Inhibitors

PI3Kγ Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

p120γ

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Sorry. There is currently no product that acts on isoform PI3Kγ together.

Please try each isoform separately.

PI3Kγ Specific Inhibitors
Product Name PI3Kγ PI3Kα PI3Kβ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3KC3 PI3Kγ Selectivity Purity
Quercetin (dihydrate)
PI3Kγ, IC50: 2.4 μM
 
PI3Kβ, IC50: 5.4 μM
PI3Kδ, IC50: 3.0 μM
          Selective Inhibitor >97.0%
IPI549
PI3Kγ, IC50: 16 nM
PI3Kα, IC50: 3.2 μM
PI3Kβ, IC50: 3.5 μM
            Selective Inhibitor 99.34%
CZC24832
PI3Kγ, IC50: 27 nM
 
PI3Kβ, IC50: 1.1 μM
PI3Kδ, IC50: 8.194 μM
          Selective Inhibitor 99.46%
AS-252424
PI3Kγ, IC50: 30 nM
PI3Kα, IC50: 935 nM
PI3Kβ, IC50: 20 μM
PI3Kδ, IC50: 20 μM
          Selective Inhibitor 97.52%
CAY10505
PI3Kγ, IC50: 30 nM (Neurons)
                Selective Inhibitor 99.79%
KU-0060648
PI3Kγ, IC50: 0.594 μM
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 0.5 nM
PI3Kδ, IC50: 0.1 nM
          Selective Inhibitor
PI3Kγ inhibitor 2
PI3Kγ, Ki: 4 nM
                Selective Inhibitor
IITZ-01
PI3Kγ, IC50: 2.62 μM
                Selective 99.80%
CGS 15943
p110γ, IC50: 1.1 μM
   
p110δ, IC50: 8.47 μM
          Selective Inhibitor
3-Methyladenine
PtdIns3Kγ, IC50: 60 μM (Cell Assay)
           
Vps34, IC50: 25 μM (Cell Assay)
  Pan Inhibitor 99.84%
Alpelisib
p110γ, IC50: 250 nM
p110α, IC50: 5 nM
p110α-H1047R, IC50: 4 nM
p110α-E545K, IC50: 4 nM
p110β, IC50: 1200 nM
p110δ, IC50: 290 nM
          Pan Inhibitor 99.90%
Copanlisib
PI3Kγ, IC50: 6.4 nM
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kδ, IC50: 0.7 nM
          Pan Inhibitor 98.91%
Buparlisib
p110γ, IC50: 262 nM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
  Pan Inhibitor 99.90%
Quercetin
PI3Kγ, IC50: 3 μM
 
PI3Kβ, IC50: 5.4 μM
PI3Kδ, IC50: 2.4 μM
          Pan Inhibitor >98.0%
Idelalisib
p110γ, IC50: 89 nM
p110α, IC50: 820 nM
p110β, IC50: 565 nM
p110δ, IC50: 2.5 nM
     
hVps34, IC50: 978 nM
  Pan Inhibitor 99.98%
Dactolisib
p110γ, IC50: 5 nM
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110δ, IC50: 7 nM
          Pan Inhibitor 99.13%
Pictilisib
p110γ, IC50: 75 nM
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110δ, IC50: 3 nM
          Pan Inhibitor 99.62%
LY3023414
PI3Kγ, IC50: 23.8 nM
PI3Kα, IC50: 6.07 nM
PI3Kβ, IC50: 77.6 nM
PI3Kδ, IC50: 38 nM
          Pan Inhibitor 99.77%
Duvelisib
p110γ, IC50: 27.4 nM
p110α, IC50: 1602 nM
p110β, IC50: 85 nM
p110δ, IC50: 2.5 nM
          Pan Inhibitor 99.91%
Fimepinostat
PI3Kγ, IC50: 311 nM
PI3Kα, IC50: 19 nM
PI3Kβ, IC50: 54 nM
PI3Kδ, IC50: 39 nM
          Pan Inhibitor 99.95%
PI-103
p110γ, IC50: 150 nM
p110α, IC50: 8 nM
p110β, IC50: 88 nM
p110δ, IC50: 48 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
 
hsVPS34, IC50: 2.3 μM
  Pan Inhibitor 99.86%
PF-04691502
PI3Kγ, Ki: 1.9 nM
PI3Kα, Ki: 1.8 nM
PI3Kβ, Ki: 2.1 nM
PI3Kδ, Ki: 1.6 nM
          Pan Inhibitor 99.49%
Omipalisib
p110γ, Ki: 0.06 nM
p110α, Ki: 0.019 nM
p110α-H1047R, Ki: 0.009 nM
p110α-E545K, Ki: 0.008 nM
p110α-E542K, Ki: 0.008 nM
p110β, Ki: 0.13 nM
p110δ, Ki: 0.024 nM
          Pan Inhibitor 99.31%
Taselisib
PI3Kγ, Ki: 0.97 nM
PI3Kα, Ki: 0.29 nM
PI3Kβ, Ki: 9.1 nM
PI3Kδ, Ki: 0.12 nM
          Pan Inhibitor 99.46%
ZSTK474
PI3Kγ, IC50: 49 nM
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 44 nM
PI3Kδ, IC50: 4.6 nM
          Pan Inhibitor 99.71%
Bimiralisib
PI3Kγ, IC50: 708 nM
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kβ, IC50: 661 nM
PI3Kδ, IC50: 451 nM
     
Vps34, IC50: 6486 nM
  Pan Inhibitor 98.90%
Gedatolisib
PI3Kγ, IC50: 5.4 nM
PI3Kα, IC50: 0.4 nM
PI3Kα-H1047R, IC50: 0.6 nM
PI3Kα-E545K, IC50: 0.6 nM
PI3Kβ, IC50: 6 nM
PI3Kδ, IC50: 6 nM
          Pan Inhibitor 99.11%
AS-605240
PI3Kγ, IC50: 8 nM
PI3Kα, IC50: 60 nM
PI3Kβ, IC50: 270 nM
PI3Kδ, IC50: 300 nM
          Pan Inhibitor >98.0%
Apitolisib
PI3Kγ, IC50: 14 nM
PI3Kα, IC50: 5 nM
PI3Kβ, IC50: 27 nM
PI3Kδ, IC50: 7 nM
          Pan Inhibitor 99.13%
Serabelisib
p110γ, IC50: 1900 nM
p110α, IC50: 15 nM
p110β, IC50: 4500 nM
p110δ, IC50: 13900 nM
          Pan Inhibitor 99.66%
Vps34-PIK-III
PI(3)Kγ, IC50: 3.04 μM
PI(3)Kα, IC50: 3.96 μM
 
PI(3)Kδ, IC50: 1.2 μM
     
Vps34, IC50: 18 nM
  Pan Inhibitor 99.73%
Pictilisib dimethanesulfonate
p110γ, IC50: 75 nM
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110δ, IC50: 3 nM
          Pan Inhibitor 99.31%
AZD 6482
PI3Kγ, IC50: 47.8 nM
PI3Kα, IC50: 136 nM
PI3Kβ, IC50: 0.69 nM
PI3Kδ, IC50: 13.6 nM
 
PI3K-C2β, IC50: 54.1 nM
 
hVps34, IC50: 3390 nM
  Pan Inhibitor 99.26%
TG100-115
PI3Kγ, IC50: 83 nM
   
PI3Kδ, IC50: 235 nM
          Pan Inhibitor 99.31%
GDC-0084
PI3Kγ, Ki: 10 nM
PI3Kα, Ki: 2 nM
PI3Kβ, Ki: 46 nM
PI3Kδ, Ki: 3 nM
          Pan Inhibitor 99.28%
Leniolisib
PI3Kγ, IC50: 2.57 μM
PI3Kα, IC50: 280 nM
PI3Kβ, IC50: 480 nM
PI3Kδ, IC50: 11 nM
          Pan Inhibitor 99.62%
AZD8186
PI3Kγ, IC50: 675 nM
PI3Kα, IC50: 35 nM
PI3Kβ, IC50: 4 nM
PI3Kδ, IC50: 12 nM
          Pan Inhibitor 99.97%
Dactolisib Tosylate
p110γ, IC50: 5 nM
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110δ, IC50: 7 nM
          Pan Inhibitor 99.89%
PI-103 Hydrochloride
p110γ, IC50: 15 nM
p110α, IC50: 2 nM
p110β, IC50: 3 nM
p110δ, IC50: 3 nM
          Pan Inhibitor 99.78%
PIK-75
p110γ, IC50: 76 nM
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
  Pan Inhibitor 99.91%
Voxtalisib
p110γ, IC50: 9 nM
p110α, IC50: 39 nM
p110β, IC50: 113 nM
p110δ, IC50: 43 nM
          Pan Inhibitor 98.93%
PIK-93
p110γ, IC50: 16 nM
p110α, IC50: 39 nM
p110β, IC50: 590 nM
p110δ, IC50: 120 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
 
hsVPS34, IC50: 320 nM
  Pan Inhibitor 99.13%
Acalisib
p110γ, IC50: 1389 nM
p110α, IC50: 5441 nM
p110β, IC50: 3377 nM
p110δ, IC50: 12.7 nM
     
hVps34, IC50: 12682 nM
  Pan Inhibitor 99.98%
SF2523
PI3Kγ, IC50: 158 nM
PI3Kα, IC50: 34 nM
              Pan Inhibitor 99.37%
SAR-260301
PI3Kγ, IC50: 10000 nM
PI3Kα, IC50: 1539 nM
PI3Kβ, IC50: 23 nM
PI3Kδ, IC50: 468 nM
   
PI3KC2γ, IC50: 3812 nM
Vps34, IC50: 183 nM
  Pan Inhibitor 99.74%
Buparlisib Hydrochloride
p110γ, IC50: 262 nM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
  Pan Inhibitor 98.01%
PI4KIIIbeta-IN-9
PI3Kγ, IC50: 1046 nM
PI3Kα, IC50: 2 μM
 
PI3Kδ, IC50: 152 nM
   
PI3KC2γ, IC50: 1 μM
    Pan Inhibitor 98.75%
Pilaralisib
PI3Kγ, IC50: 23 nM
PI3Kα, IC50: 39 nM
PI3Kβ, IC50: 383 nM
PI3Kδ, IC50: 36 nM
     
Vps34, IC50: 6974 nM
  Pan Inhibitor 99.57%
IC-87114
PI3Kγ, IC50: 29 μM
 
PI3Kβ, IC50: 75 μM
PI3Kδ, IC50: 0.5 μM
          Pan Inhibitor 98.66%
Nemiralisib
PI3Kγ, pIC50: 5.2
PI3Kα, pIC50: 5.3
PI3Kβ, pIC50: 5.8
PI3Kδ, pKi: 9.9
          Pan Inhibitor 99.50%
PKI-402
PI3Kγ, IC50: 16 nM
PI3Kα, IC50: 2 nM
PI3Kα-H1047R, IC50: 3 nM
PI3Kα-E545K, IC50: 3 nM
PI3Kβ, IC50: 7 nM
PI3Kδ, IC50: 14 nM
          Pan Inhibitor 99.44%
PIK-90
p110γ, IC50: 18 nM
p110α, IC50: 11 nM
p110β, IC50: 350 nM
p110δ, IC50: 58 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
 
hsVPS34, IC50: 830 nM
  Pan Inhibitor 99.06%
Tenalisib
PI3Kγ, IC50: 33 nM
   
PI3Kδ, IC50: 25 nM
          Pan Inhibitor 99.09%
PF-04979064
PI3Kγ, Ki: 0.111 nM
PI3Kα, Ki: 0.13 nM
 
PI3Kδ, Ki: 0.122 nM
          Pan Inhibitor 99.75%
BGT226 maleate
PI3Kγ, IC50: 38 nM
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 63 nM
            Pan Inhibitor 99.76%
CH5132799
PI3Kγ, IC50: 36 nM
PI3Kα, IC50: 14 nM
PI3Kα-H1047R, IC50: 5.6 nM
PI3Kα-E545K, IC50: 6.7 nM
PI3Kα-E542K, IC50: 6.7 nM
PI3Kβ, IC50: 120 nM
PI3Kδ, IC50: 500 nM
 
PI3KC2β, IC50: 5.3 μM
      Pan Inhibitor >98.0%
GSK1059615
PI3Kγ, IC50: 2 nM
PI3Kα, IC50: 0.4 nM
PI3Kβ, IC50: 0.6 nM
PI3Kδ, IC50: 5 nM
          Pan Inhibitor 98.91%
A66
p110γ, IC50: 3480 nM
p110α, IC50: 32 nM
p110α E545K, IC50: 30 nM
p110α H1047R, IC50: 43 nM
     
PI3K-C2β, IC50: 462 nM
      Pan Inhibitor 99.26%
AZD-8835
PI3Kγ, IC50: 90 nM
PI3Kα, IC50: 6.2 nM
PI3Kα-E545K, IC50: 6 nM
PI3Kα-H1047R, IC50: 5.8 nM
PI3Kβ, IC50: 431 nM
PI3Kδ, IC50: 5.7 nM
          Pan Inhibitor 98.93%
CNX-1351
PI3Kγ, IC50: 3020 nM
PI3Kα, IC50: 6.8 nM
PI3Kβ, IC50: 166 nM
PI3Kδ, IC50: 240.3 nM
          Pan Inhibitor 99.88%
GNE-493
PI3Kγ, IC50: 16 nM
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 12 nM
PI3Kδ, IC50: 16 nM
          Pan Inhibitor 95.12%
VS-5584
PI3Kγ, IC50: 25 nM
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 68 nM
PI3Kδ, IC50: 42 nM
     
Vps34, IC50: 7470 nM
  Pan Inhibitor 98.01%
GDC-0326
PI3Kγ, Ki: 10.2 nM
PI3Kα, Ki: 0.2 nM
PI3Kβ, Ki: 26.6 nM
PI3Kδ, Ki: 4 nM
          Pan Inhibitor 99.31%
ETP-46321
p110γ, Ki: 179 nM
p110α, Ki: 2.3 nM
PI3Kα-H1047R, Ki: 2.33 nM
PI3Kα-E545K, Ki: 1.77 nM
PI3Kα-E542K, Ki: 1.89 nM
p110β, Ki: 170 nM
p110δ, Ki: 14.2 nM
          Pan Inhibitor >98.0%
PIK-294
p110γ, IC50: 160 nM
p110α, IC50: 10 μM
p110β, IC50: 490 nM
p110δ, IC50: 10 nM
          Pan Inhibitor 99.88%
AMG319
PI3Kγ, IC50: 850 nM
PI3Kα, IC50: 33 μM
PI3Kβ, IC50: 2.7 μM
PI3Kδ, IC50: 18 nM
          Pan Inhibitor 98.40%
NSC781406
PI3Kγ, IC50: 2.7 nM
PI3Kα, IC50: 2 nM
PI3Kβ, IC50: 9.4 nM
PI3Kδ, IC50: 14 nM
          Pan Inhibitor 99.55%
IPI-3063
p110γ, IC50: 2187 nM
p110α, IC50: 1170 nM
p110β, IC50: 1508 nM
p110δ, IC50: 2.5 nM
          Pan Inhibitor 98.80%
WYE-687
PI3K gamma, IC50: 3.11 μM
PI3K alpha, IC50: 81 nM
              Pan Inhibitor
CAL-130 Hydrochloride
p110γ, IC50: 6.1 nM
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110δ, IC50: 1.3 nM
          Pan Inhibitor 99.88%
BGT226
PI3Kγ, IC50: 38 nM
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 63 nM
            Pan Inhibitor
PI3Kγ inhibitor 3
PI3Kγ, pIC50: 9.1
PI3Kα, pIC50: 5.1
PI3Kβ, pIC50: 4.5
PI3Kδ, pIC50: 6.5
PI3KC2α, pIC50: 5
PI3KC2β, pIC50: 7.5
PI3KC2γ, pIC50: 5.5
 
PI3KC3, pIC50: 5.1
Pan Inhibitor
CHMFL-PI3KD-317
PI3Kγ, IC50: 202.7 nM
PI3Kα, IC50: 62.6 nM
PI3Kβ, IC50: 284 nM
PI3Kδ, IC50: 6 nM
 
PIK3C2B, IC50: 882.3 nM
 
Vps34, IC50: 1801.7 nM
  Pan Inhibitor
PI3K/HDAC-IN-1
PI3Kγ, IC50: 67 nM
PI3Kα, IC50: 42 nM
PI3Kβ, IC50: 101 nM
PI3Kδ, IC50: 8.1 nM
          Pan Inhibitor
PI3K/mTOR Inhibitor-2
PI3Kγ, IC50: 1 nM
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 34 nM
PI3Kδ, IC50: 16 nM
          Pan Inhibitor 99.45%
PI3K-IN-2
PI3Kγ, IC50: 8.6 nM
PI3Kα, IC50: 13 nM
PI3Kβ, IC50: 7.1 nM
PI3Kδ, IC50: 190 nM
          Pan Inhibitor
PI3K/mTOR Inhibitor-1
PI3Kγ, IC50: 204 nM
PI3Kα, IC50: 20 nM
PI3Kβ, IC50: 376 nM
PI3Kδ, IC50: 46 nM
          Pan Inhibitor
WYE-687 dihydrochloride
PI3K gamma, IC50: 3.11 μM
PI3K alpha, IC50: 81 nM
              Pan Inhibitor >98.0%
NVP-BAG956
PI3Kγ, IC50: 117 nM
PI3Kα, IC50: 56 nM
PI3Kβ, IC50: 446 nM
PI3Kδ, IC50: 35 nM
          Pan Inhibitor
PI3Kγ inhibitor 1
PI3Kγ, IC50: 100 nM
PI3Kα, IC50: 10 μM
PI3Kβ, IC50: 10 μM
PI3Kδ, IC50: 100 nM
          Pan Inhibitor
ON 146040
PI3Kγ, IC50: 1 μM
PI3Kα, IC50: 14 nM
PI3Kβ, IC50: 3 μM
PI3Kδ, IC50: 20 nM
          Pan Inhibitor
CAL-130
p110γ, IC50: 6.1 nM
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110δ, IC50: 1.3 nM
          Pan Inhibitor