1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kδ Inhibitors

PI3Kδ Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

p120γ

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Sorry. There is currently no product that acts on isoform PI3Kδ together.

Please try each isoform separately.

PI3Kδ Specific Inhibitors
Product Name PI3Kδ PI3Kα PI3Kβ PI3Kγ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3KC3 p120γ PI3Kδ Selectivity Purity
GS-9901
PI3Kδ, IC50: 1 nM
                  Selective Inhibitor
Idelalisib
p110δ, IC50: 2.5 nM
p110α, IC50: 820 nM
p110β, IC50: 565 nM
p110γ, IC50: 89 nM
     
hVps34, IC50: 978 nM
    Selective Inhibitor 99.98%
Duvelisib
p110δ, IC50: 2.5 nM
p110α, IC50: 1602 nM
p110β, IC50: 85 nM
p110γ, IC50: 27.4 nM
            Selective Inhibitor 99.91%
Umbralisib
PI3Kδ, IC50: 22.2 nM
                  Selective Inhibitor 98.55%
Leniolisib
PI3Kδ, IC50: 11 nM
PI3Kα, IC50: 280 nM
PI3Kβ, IC50: 480 nM
PI3Kγ, IC50: 2.57 μM
            Selective Inhibitor 99.62%
Seletalisib
PI3Kδ, IC50: 12 nM
                  Selective Inhibitor 99.59%
Acalisib
p110δ, IC50: 12.7 nM
p110α, IC50: 5441 nM
p110β, IC50: 3377 nM
p110γ, IC50: 1389 nM
     
hVps34, IC50: 12682 nM
    Selective Inhibitor 99.98%
IC-87114
PI3Kδ, IC50: 0.5 μM
 
PI3Kβ, IC50: 75 μM
PI3Kγ, IC50: 29 μM
            Selective Inhibitor 98.66%
Nemiralisib
PI3Kδ, pKi: 9.9
PI3Kα, pIC50: 5.3
PI3Kβ, pIC50: 5.8
PI3Kγ, pIC50: 5.2
            Selective Inhibitor 99.50%
PI3Kδ-IN-2
PI3Kδ, IC50: 6.4 nM
                  Selective Inhibitor 98.95%
Umbralisib hydrochloride
PI3Kδ, IC50: 22.2 nM
                  Selective Inhibitor 99.63%
PI-3065
p110δ, IC50: 5 nM
p110α, IC50: 910 nM
p110β, IC50: 600 nM
              Selective Inhibitor 98.27%
PIK-294
p110δ, IC50: 10 nM
p110α, IC50: 10 μM
p110β, IC50: 490 nM
p110γ, IC50: 160 nM
            Selective Inhibitor 99.88%
AMG319
PI3Kδ, IC50: 18 nM
PI3Kα, IC50: 33 μM
PI3Kβ, IC50: 2.7 μM
PI3Kγ, IC50: 850 nM
            Selective Inhibitor 98.40%
IPI-3063
p110δ, IC50: 2.5 nM
p110α, IC50: 1170 nM
p110β, IC50: 1508 nM
p110γ, IC50: 2187 nM
            Selective Inhibitor 98.80%
KU-0060648
PI3Kδ, IC50: 0.1 nM
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 0.5 nM
PI3Kγ, IC50: 0.594 μM
            Selective Inhibitor
PI3Kdelta inhibitor 1
PI3Kδ, IC50: 1.3 nM
                  Selective Inhibitor
LAS191954
PI3Kδ, IC50: 2.6 nM
                  Selective Inhibitor
CHMFL-PI3KD-317
PI3Kδ, IC50: 6 nM
PI3Kα, IC50: 62.6 nM
PI3Kβ, IC50: 284 nM
PI3Kγ, IC50: 202.7 nM
 
PIK3C2B, IC50: 882.3 nM
 
Vps34, IC50: 1801.7 nM
    Selective Inhibitor
Quercetin (dihydrate)
PI3Kδ, IC50: 3.0 μM
 
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 2.4 μM
            Selective Inhibitor
Umbralisib R-enantiomer
PI3Kδ
                  Selective Inhibitor 98.82%
CAL-130 Racemate
PI3Kδ
                  Selective Inhibitor
PI3kδ inhibitor 1
PI3Kδ, IC50: 3.8 nM
                  Selective Inhibitor
LY294002
p110δ, IC50: 0.57 μM
p110α, IC50: 0.5 μM
p110β, IC50: 0.97 μM
              Pan Inhibitor 99.95%
Alpelisib
p110δ, IC50: 290 nM
p110α, IC50: 5 nM
p110α-H1047R, IC50: 4 nM
p110α-E545K, IC50: 4 nM
p110β, IC50: 1200 nM
p110γ, IC50: 250 nM
            Pan Inhibitor 99.90%
Copanlisib
PI3Kδ, IC50: 0.7 nM
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
            Pan Inhibitor 98.91%
Buparlisib
p110δ, IC50: 116 nM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
     
Vps34, IC50: 2.4 μM
    Pan Inhibitor 99.90%
Quercetin
PI3Kδ, IC50: 2.4 μM
 
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 3 μM
            Pan Inhibitor >98.0%
Dactolisib
p110δ, IC50: 7 nM
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
            Pan Inhibitor 99.13%
Pictilisib
p110δ, IC50: 3 nM
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
            Pan Inhibitor 99.62%
LY3023414
PI3Kδ, IC50: 38 nM
PI3Kα, IC50: 6.07 nM
PI3Kβ, IC50: 77.6 nM
PI3Kγ, IC50: 23.8 nM
            Pan Inhibitor 99.77%
Fimepinostat
PI3Kδ, IC50: 39 nM
PI3Kα, IC50: 19 nM
PI3Kβ, IC50: 54 nM
PI3Kγ, IC50: 311 nM
            Pan Inhibitor 99.95%
PI-103
p110δ, IC50: 48 nM
p110α, IC50: 8 nM
p110β, IC50: 88 nM
p110γ, IC50: 150 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
 
hsVPS34, IC50: 2.3 μM
    Pan Inhibitor 99.86%
PF-04691502
PI3Kδ, Ki: 1.6 nM
PI3Kα, Ki: 1.8 nM
PI3Kβ, Ki: 2.1 nM
PI3Kγ, Ki: 1.9 nM
            Pan Inhibitor 99.49%
Omipalisib
p110δ, Ki: 0.024 nM
p110α, Ki: 0.019 nM
p110α-H1047R, Ki: 0.009 nM
p110α-E545K, Ki: 0.008 nM
p110α-E542K, Ki: 0.008 nM
p110β, Ki: 0.13 nM
p110γ, Ki: 0.06 nM
            Pan Inhibitor 99.31%
Taselisib
PI3Kδ, Ki: 0.12 nM
PI3Kα, Ki: 0.29 nM
PI3Kβ, Ki: 9.1 nM
PI3Kγ, Ki: 0.97 nM
            Pan Inhibitor 99.46%
Bimiralisib
PI3Kδ, IC50: 451 nM
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kβ, IC50: 661 nM
PI3Kγ, IC50: 708 nM
     
Vps34, IC50: 6486 nM
    Pan Inhibitor 98.90%
AS-605240
PI3Kδ, IC50: 300 nM
PI3Kα, IC50: 60 nM
PI3Kβ, IC50: 270 nM
PI3Kγ, IC50: 8 nM
            Pan Inhibitor >98.0%
Gedatolisib
PI3Kδ, IC50: 6 nM
PI3Kα, IC50: 0.4 nM
PI3Kα-H1047R, IC50: 0.6 nM
PI3Kα-E545K, IC50: 0.6 nM
PI3Kβ, IC50: 6 nM
PI3Kγ, IC50: 5.4 nM
            Pan Inhibitor 99.11%
ZSTK474
PI3Kδ, IC50: 4.6 nM
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 44 nM
PI3Kγ, IC50: 49 nM
            Pan Inhibitor 99.71%
Apitolisib
PI3Kδ, IC50: 7 nM
PI3Kα, IC50: 5 nM
PI3Kβ, IC50: 27 nM
PI3Kγ, IC50: 14 nM
            Pan Inhibitor 99.13%
Vps34-PIK-III
PI(3)Kδ, IC50: 1.2 μM
PI(3)Kα, IC50: 3.96 μM
 
PI(3)Kγ, IC50: 3.04 μM
     
Vps34, IC50: 18 nM
    Pan Inhibitor 99.73%
AZD 6482
PI3Kδ, IC50: 13.6 nM
PI3Kα, IC50: 136 nM
PI3Kβ, IC50: 0.69 nM
PI3Kγ, IC50: 47.8 nM
 
PI3K-C2β, IC50: 54.1 nM
 
hVps34, IC50: 3390 nM
    Pan Inhibitor 99.26%
TGX-221
p110δ, IC50: 211 nM
 
p110β, IC50: 8.5 nM
              Pan Inhibitor 99.78%
PI-103 Hydrochloride
p110δ, IC50: 3 nM
p110α, IC50: 2 nM
p110β, IC50: 3 nM
p110γ, IC50: 15 nM
            Pan Inhibitor 99.78%
Serabelisib
p110δ, IC50: 13900 nM
p110α, IC50: 15 nM
p110β, IC50: 4500 nM
p110γ, IC50: 1900 nM
            Pan Inhibitor 99.66%
AZD8186
PI3Kδ, IC50: 12 nM
PI3Kα, IC50: 35 nM
PI3Kβ, IC50: 4 nM
PI3Kγ, IC50: 675 nM
            Pan Inhibitor 99.97%
Voxtalisib
p110δ, IC50: 43 nM
p110α, IC50: 39 nM
p110β, IC50: 113 nM
p110γ, IC50: 9 nM
            Pan Inhibitor 98.93%
PIK-93
p110δ, IC50: 120 nM
p110α, IC50: 39 nM
p110β, IC50: 590 nM
p110γ, IC50: 16 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
 
hsVPS34, IC50: 320 nM
    Pan Inhibitor 99.13%
TG100-115
PI3Kδ, IC50: 235 nM
   
PI3Kγ, IC50: 83 nM
            Pan Inhibitor 99.31%
Pictilisib dimethanesulfonate
p110δ, IC50: 3 nM
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
            Pan Inhibitor 99.12%
PIK-75
p110δ, IC50: 510 nM
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110γ, IC50: 76 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
    Pan Inhibitor 99.91%
GDC-0084
PI3Kδ, Ki: 3 nM
PI3Kα, Ki: 2 nM
PI3Kβ, Ki: 46 nM
PI3Kγ, Ki: 10 nM
            Pan Inhibitor 99.28%
Dactolisib Tosylate
p110δ, IC50: 7 nM
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
            Pan Inhibitor 99.89%
Pilaralisib
PI3Kδ, IC50: 36 nM
PI3Kα, IC50: 39 nM
PI3Kβ, IC50: 383 nM
PI3Kγ, IC50: 23 nM
     
Vps34, IC50: 6974 nM
    Pan Inhibitor 99.57%
Buparlisib Hydrochloride
p110δ, IC50: 116 nM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
     
Vps34, IC50: 2.4 μM
    Pan Inhibitor 98.01%
PI4KIIIbeta-IN-9
PI3Kδ, IC50: 152 nM
PI3Kα, IC50: 2 μM
 
PI3Kγ, IC50: 1046 nM
   
PI3KC2γ, IC50: 1 μM
      Pan Inhibitor 98.16%
SAR-260301
PI3Kδ, IC50: 468 nM
PI3Kα, IC50: 1539 nM
PI3Kβ, IC50: 23 nM
PI3Kγ, IC50: 10000 nM
   
PI3KC2γ, IC50: 3812 nM
Vps34, IC50: 183 nM
    Pan Inhibitor 99.74%
AS-252424
PI3Kδ, IC50: 20 μM
PI3Kα, IC50: 935 nM
PI3Kβ, IC50: 20 μM
PI3Kγ, IC50: 30 nM
            Pan Inhibitor 97.52%
Tenalisib
PI3Kδ, IC50: 25 nM
   
PI3Kγ, IC50: 33 nM
            Pan Inhibitor 99.09%
AZD-8835
PI3Kδ, IC50: 5.7 nM
PI3Kα, IC50: 6.2 nM
PI3Kα-E545K, IC50: 6 nM
PI3Kα-H1047R, IC50: 5.8 nM
PI3Kβ, IC50: 431 nM
PI3Kγ, IC50: 90 nM
            Pan Inhibitor 98.93%
PIK-90
p110δ, IC50: 58 nM
p110α, IC50: 11 nM
p110β, IC50: 350 nM
p110γ, IC50: 18 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
 
hsVPS34, IC50: 830 nM
    Pan Inhibitor 99.06%
PF-04979064
PI3Kδ, Ki: 0.122 nM
PI3Kα, Ki: 0.13 nM
 
PI3Kγ, Ki: 0.111 nM
            Pan Inhibitor 99.75%
PKI-402
PI3Kδ, IC50: 14 nM
PI3Kα, IC50: 2 nM
PI3Kα-H1047R, IC50: 3 nM
PI3Kα-E545K, IC50: 3 nM
PI3Kβ, IC50: 7 nM
PI3Kγ, IC50: 16 nM
            Pan Inhibitor 99.44%
CZC24832
PI3Kδ, IC50: 8.194 μM
 
PI3Kβ, IC50: 1.1 μM
PI3Kγ, IC50: 27 nM
            Pan Inhibitor 98.01%
CH5132799
PI3Kδ, IC50: 500 nM
PI3Kα, IC50: 14 nM
PI3Kα-H1047R, IC50: 5.6 nM
PI3Kα-E545K, IC50: 6.7 nM
PI3Kα-E542K, IC50: 6.7 nM
PI3Kβ, IC50: 120 nM
PI3Kγ, IC50: 36 nM
 
PI3KC2β, IC50: 5.3 μM
        Pan Inhibitor >98.0%
GSK1059615
PI3Kδ, IC50: 5 nM
PI3Kα, IC50: 0.4 nM
PI3Kβ, IC50: 0.6 nM
PI3Kγ, IC50: 2 nM
            Pan Inhibitor 98.91%
GDC-0326
PI3Kδ, Ki: 4 nM
PI3Kα, Ki: 0.2 nM
PI3Kβ, Ki: 26.6 nM
PI3Kγ, Ki: 10.2 nM
            Pan Inhibitor 99.31%
CNX-1351
PI3Kδ, IC50: 240.3 nM
PI3Kα, IC50: 6.8 nM
PI3Kβ, IC50: 166 nM
PI3Kγ, IC50: 3020 nM
            Pan Inhibitor 99.88%
GNE-493
PI3Kδ, IC50: 16 nM
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 12 nM
PI3Kγ, IC50: 16 nM
            Pan Inhibitor 95.12%
VS-5584
PI3Kδ, IC50: 42 nM
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 68 nM
PI3Kγ, IC50: 25 nM
     
Vps34, IC50: 7470 nM
    Pan Inhibitor 98.01%
NSC781406
PI3Kδ, IC50: 14 nM
PI3Kα, IC50: 2 nM
PI3Kβ, IC50: 9.4 nM
PI3Kγ, IC50: 2.7 nM
            Pan Inhibitor 99.55%
ETP-46321
p110δ, Ki: 14.2 nM
p110α, Ki: 2.3 nM
PI3Kα-H1047R, Ki: 2.33 nM
PI3Kα-E545K, Ki: 1.77 nM
PI3Kα-E542K, Ki: 1.89 nM
p110β, Ki: 170 nM
p110γ, Ki: 179 nM
            Pan Inhibitor >98.0%
CAL-130 Hydrochloride
p110δ, IC50: 1.3 nM
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
            Pan Inhibitor 99.88%
PI3K-IN-6
PI3Kδ, IC50: 5.3 nM
PI3Kα, IC50: 850 nM
PI3Kβ, IC50: 7.8 nM
              Pan Inhibitor
PI3Kγ inhibitor 3
PI3Kδ, pIC50: 6.5
PI3Kα, pIC50: 5.1
PI3Kβ, pIC50: 4.5
PI3Kγ, pIC50: 9.1
PI3KC2α, pIC50: 5
PI3KC2β, pIC50: 7.5
PI3KC2γ, pIC50: 5.5
 
PI3KC3, pIC50: 5.1
  Pan Inhibitor
PI3K/HDAC-IN-1
PI3Kδ, IC50: 8.1 nM
PI3Kα, IC50: 42 nM
PI3Kβ, IC50: 101 nM
PI3Kγ, IC50: 67 nM
            Pan Inhibitor
PI3K/mTOR Inhibitor-2
PI3Kδ, IC50: 16 nM
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 34 nM
PI3Kγ, IC50: 1 nM
            Pan Inhibitor
PI3K/mTOR Inhibitor-1
PI3Kδ, IC50: 46 nM
PI3Kα, IC50: 20 nM
PI3Kβ, IC50: 376 nM
PI3Kγ, IC50: 204 nM
            Pan Inhibitor
Sonolisib
p110δ, IC50: 2.9 nM
p110α, IC50: 0.1 nM
             
p120γ, IC50: 1 nM
Pan Inhibitor
NVP-BAG956
PI3Kδ, IC50: 35 nM
PI3Kα, IC50: 56 nM
PI3Kβ, IC50: 446 nM
PI3Kγ, IC50: 117 nM
            Pan Inhibitor
PI3Kγ inhibitor 1
PI3Kδ, IC50: 100 nM
PI3Kα, IC50: 10 μM
PI3Kβ, IC50: 10 μM
PI3Kγ, IC50: 100 nM
            Pan Inhibitor
ON 146040
PI3Kδ, IC50: 20 nM
PI3Kα, IC50: 14 nM
PI3Kβ, IC50: 3 μM
PI3Kγ, IC50: 1 μM
            Pan Inhibitor
CAL-130
p110δ, IC50: 1.3 nM
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
            Pan Inhibitor