1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kβ Inhibitors

PI3Kβ Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

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Sorry. There is currently no product that acts on isoform PI3Kβ together.

Please try each isoform separately.

PI3Kβ Specific Inhibitors
Product Name PI3Kβ PI3Kα PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3KC3 PI3Kβ Selectivity Purity
GSK2636771
p110β
                Selective Inhibitor 99.10%
TGX-221
p110β, IC50: 8.5 nM
   
p110δ, IC50: 211 nM
          Selective Inhibitor 99.78%
SAR-260301
PI3Kβ, IC50: 23 nM
PI3Kα, IC50: 1539 nM
PI3Kγ, IC50: 10000 nM
PI3Kδ, IC50: 468 nM
   
PI3KC2γ, IC50: 3812 nM
Vps34, IC50: 183 nM
  Selective Inhibitor 99.74%
LY294002
p110β, IC50: 0.97 μM
p110α, IC50: 0.5 μM
 
p110δ, IC50: 0.57 μM
          Pan Inhibitor 99.95%
Alpelisib
p110β, IC50: 1200 nM
p110α, IC50: 5 nM
p110α-H1047R, IC50: 4 nM
p110α-E545K, IC50: 4 nM
p110γ, IC50: 250 nM
p110δ, IC50: 290 nM
          Pan Inhibitor 99.90%
Buparlisib
p110β, IC50: 166 nM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
  Pan Inhibitor 99.90%
BGT226
PI3Kβ, IC50: 63 nM
PI3Kα, IC50: 4 nM
PI3Kγ, IC50: 38 nM
            Pan Inhibitor
Copanlisib
PI3Kβ, IC50: 3.7 nM
PI3Kα, IC50: 0.5 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
          Pan Inhibitor 98.91%
Quercetin
PI3Kβ, IC50: 5.4 μM
 
PI3Kγ, IC50: 3 μM
PI3Kδ, IC50: 2.4 μM
          Pan Inhibitor >98.0%
Idelalisib
p110β, IC50: 565 nM
p110α, IC50: 820 nM
p110γ, IC50: 89 nM
p110δ, IC50: 2.5 nM
     
hVps34, IC50: 978 nM
  Pan Inhibitor 99.98%
IPI549
PI3Kβ, IC50: 3.5 μM
PI3Kα, IC50: 3.2 μM
PI3Kγ, IC50: 16 nM
            Pan Inhibitor 99.34%
Dactolisib
p110β, IC50: 75 nM
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
          Pan Inhibitor 99.13%
Pictilisib
p110β, IC50: 33 nM
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
          Pan Inhibitor 99.62%
LY3023414
PI3Kβ, IC50: 77.6 nM
PI3Kα, IC50: 6.07 nM
PI3Kγ, IC50: 23.8 nM
PI3Kδ, IC50: 38 nM
          Pan Inhibitor 99.77%
Fimepinostat
PI3Kβ, IC50: 54 nM
PI3Kα, IC50: 19 nM
PI3Kγ, IC50: 311 nM
PI3Kδ, IC50: 39 nM
          Pan Inhibitor 99.95%
Duvelisib
p110β, IC50: 85 nM
p110α, IC50: 1602 nM
p110γ, IC50: 27.4 nM
p110δ, IC50: 2.5 nM
          Pan Inhibitor 99.91%
PF-04691502
PI3Kβ, Ki: 2.1 nM
PI3Kα, Ki: 1.8 nM
PI3Kγ, Ki: 1.9 nM
PI3Kδ, Ki: 1.6 nM
          Pan Inhibitor 99.49%
Omipalisib
p110β, Ki: 0.13 nM
p110α, Ki: 0.019 nM
p110α-H1047R, Ki: 0.009 nM
p110α-E545K, Ki: 0.008 nM
p110α-E542K, Ki: 0.008 nM
p110γ, Ki: 0.06 nM
p110δ, Ki: 0.024 nM
          Pan Inhibitor 99.31%
PI-103
p110β, IC50: 88 nM
p110α, IC50: 8 nM
p110γ, IC50: 150 nM
p110δ, IC50: 48 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
 
hsVPS34, IC50: 2.3 μM
  Pan Inhibitor 99.86%
Taselisib
PI3Kβ, Ki: 9.1 nM
PI3Kα, Ki: 0.29 nM
PI3Kγ, Ki: 0.97 nM
PI3Kδ, Ki: 0.12 nM
          Pan Inhibitor 99.75%
Bimiralisib
PI3Kβ, IC50: 661 nM
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kγ, IC50: 708 nM
PI3Kδ, IC50: 451 nM
     
Vps34, IC50: 6486 nM
  Pan Inhibitor 98.90%
AS-605240
PI3Kβ, IC50: 270 nM
PI3Kα, IC50: 60 nM
PI3Kγ, IC50: 8 nM
PI3Kδ, IC50: 300 nM
          Pan Inhibitor >98.0%
ZSTK474
PI3Kβ, IC50: 44 nM
PI3Kα, IC50: 16 nM
PI3Kγ, IC50: 49 nM
PI3Kδ, IC50: 4.6 nM
          Pan Inhibitor 99.71%
Gedatolisib
PI3Kβ, IC50: 6 nM
PI3Kα, IC50: 0.4 nM
PI3Kα-H1047R, IC50: 0.6 nM
PI3Kα-E545K, IC50: 0.6 nM
PI3Kγ, IC50: 5.4 nM
PI3Kδ, IC50: 6 nM
          Pan Inhibitor 99.11%
PI-103 Hydrochloride
p110β, IC50: 3 nM
p110α, IC50: 2 nM
p110γ, IC50: 15 nM
p110δ, IC50: 3 nM
          Pan Inhibitor 99.78%
Apitolisib
PI3Kβ, IC50: 27 nM
PI3Kα, IC50: 5 nM
PI3Kγ, IC50: 14 nM
PI3Kδ, IC50: 7 nM
          Pan Inhibitor 99.13%
Serabelisib
p110β, IC50: 4500 nM
p110α, IC50: 15 nM
p110γ, IC50: 1900 nM
p110δ, IC50: 13900 nM
          Pan Inhibitor 99.66%
PIK-75
p110β, IC50: 1.3 μM
p110α, IC50: 5.8 nM
p110γ, IC50: 76 nM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
  Pan Inhibitor 99.91%
Voxtalisib
p110β, IC50: 113 nM
p110α, IC50: 39 nM
p110γ, IC50: 9 nM
p110δ, IC50: 43 nM
          Pan Inhibitor 98.93%
GDC-0084
PI3Kβ, Ki: 46 nM
PI3Kα, Ki: 2 nM
PI3Kγ, Ki: 10 nM
PI3Kδ, Ki: 3 nM
          Pan Inhibitor 99.28%
PIK-93
p110β, IC50: 590 nM
p110α, IC50: 39 nM
p110γ, IC50: 16 nM
p110δ, IC50: 120 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
 
hsVPS34, IC50: 320 nM
  Pan Inhibitor 99.13%
Buparlisib Hydrochloride
p110β, IC50: 166 nM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
  Pan Inhibitor 98.01%
Leniolisib
PI3Kβ, IC50: 480 nM
PI3Kα, IC50: 280 nM
PI3Kγ, IC50: 2.57 μM
PI3Kδ, IC50: 11 nM
          Pan Inhibitor 99.62%
AZD8186
PI3Kβ, IC50: 4 nM
PI3Kα, IC50: 35 nM
PI3Kγ, IC50: 675 nM
PI3Kδ, IC50: 12 nM
          Pan Inhibitor 99.97%
Pilaralisib
PI3Kβ, IC50: 383 nM
PI3Kα, IC50: 39 nM
PI3Kγ, IC50: 23 nM
PI3Kδ, IC50: 36 nM
     
Vps34, IC50: 6974 nM
  Pan Inhibitor 98.35%
Pictilisib dimethanesulfonate
p110β, IC50: 33 nM
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
          Pan Inhibitor 99.12%
Dactolisib Tosylate
p110β, IC50: 75 nM
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
          Pan Inhibitor 99.89%
Acalisib
p110β, IC50: 3377 nM
p110α, IC50: 5441 nM
p110γ, IC50: 1389 nM
p110δ, IC50: 12.7 nM
     
hVps34, IC50: 12682 nM
  Pan Inhibitor 99.98%
AZD-8835
PI3Kβ, IC50: 431 nM
PI3Kα, IC50: 6.2 nM
PI3Kα-E545K, IC50: 6 nM
PI3Kα-H1047R, IC50: 5.8 nM
PI3Kγ, IC50: 90 nM
PI3Kδ, IC50: 5.7 nM
          Pan Inhibitor 98.93%
AS-252424
PI3Kβ, IC50: 20 μM
PI3Kα, IC50: 935 nM
PI3Kγ, IC50: 30 nM
PI3Kδ, IC50: 20 μM
          Pan Inhibitor 97.52%
IC-87114
PI3Kβ, IC50: 75 μM
 
PI3Kγ, IC50: 29 μM
PI3Kδ, IC50: 0.5 μM
          Pan Inhibitor 98.66%
BGT226 maleate
PI3Kβ, IC50: 63 nM
PI3Kα, IC50: 4 nM
PI3Kγ, IC50: 38 nM
            Pan Inhibitor 99.76%
PKI-402
PI3Kβ, IC50: 7 nM
PI3Kα, IC50: 2 nM
PI3Kα-H1047R, IC50: 3 nM
PI3Kα-E545K, IC50: 3 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 14 nM
          Pan Inhibitor 99.44%
PIK-90
p110β, IC50: 350 nM
p110α, IC50: 11 nM
p110γ, IC50: 18 nM
p110δ, IC50: 58 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
 
hsVPS34, IC50: 830 nM
  Pan Inhibitor 99.06%
Nemiralisib
PI3Kβ, pIC50: 5.8
PI3Kα, pIC50: 5.3
PI3Kγ, pIC50: 5.2
PI3Kδ, pKi: 9.9
          Pan Inhibitor 99.50%
CZC24832
PI3Kβ, IC50: 1.1 μM
 
PI3Kγ, IC50: 27 nM
PI3Kδ, IC50: 8.194 μM
          Pan Inhibitor 98.01%
CH5132799
PI3Kβ, IC50: 120 nM
PI3Kα, IC50: 14 nM
PI3Kα-H1047R, IC50: 5.6 nM
PI3Kα-E545K, IC50: 6.7 nM
PI3Kα-E542K, IC50: 6.7 nM
PI3Kγ, IC50: 36 nM
PI3Kδ, IC50: 500 nM
 
PI3KC2β, IC50: 5.3 μM
      Pan Inhibitor >98.0%
CNX-1351
PI3Kβ, IC50: 166 nM
PI3Kα, IC50: 6.8 nM
PI3Kγ, IC50: 3020 nM
PI3Kδ, IC50: 240.3 nM
          Pan Inhibitor 99.88%
GSK1059615
PI3Kβ, IC50: 0.6 nM
PI3Kα, IC50: 0.4 nM
PI3Kγ, IC50: 2 nM
PI3Kδ, IC50: 5 nM
          Pan Inhibitor 98.91%
GNE-493
PI3Kβ, IC50: 12 nM
PI3Kα, IC50: 3.4 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 16 nM
          Pan Inhibitor 95.12%
GDC-0326
PI3Kβ, Ki: 26.6 nM
PI3Kα, Ki: 0.2 nM
PI3Kγ, Ki: 10.2 nM
PI3Kδ, Ki: 4 nM
          Pan Inhibitor 99.31%
PI-3065
p110β, IC50: 600 nM
p110α, IC50: 910 nM
 
p110δ, IC50: 5 nM
          Pan Inhibitor 98.27%
VS-5584
PI3Kβ, IC50: 68 nM
PI3Kα, IC50: 16 nM
PI3Kγ, IC50: 25 nM
PI3Kδ, IC50: 42 nM
     
Vps34, IC50: 7470 nM
  Pan Inhibitor 98.01%
PIK-294
p110β, IC50: 490 nM
p110α, IC50: 10 μM
p110γ, IC50: 160 nM
p110δ, IC50: 10 nM
          Pan Inhibitor 99.88%
NSC781406
PI3Kβ, IC50: 9.4 nM
PI3Kα, IC50: 2 nM
PI3Kγ, IC50: 2.7 nM
PI3Kδ, IC50: 14 nM
          Pan Inhibitor 99.55%
AMG319
PI3Kβ, IC50: 2.7 μM
PI3Kα, IC50: 33 μM
PI3Kγ, IC50: 850 nM
PI3Kδ, IC50: 18 nM
          Pan Inhibitor 98.40%
IPI-3063
p110β, IC50: 1508 nM
p110α, IC50: 1170 nM
p110γ, IC50: 2187 nM
p110δ, IC50: 2.5 nM
          Pan Inhibitor 98.80%
ETP-46321
p110β, Ki: 170 nM
p110α, Ki: 2.3 nM
PI3Kα-H1047R, Ki: 2.33 nM
PI3Kα-E545K, Ki: 1.77 nM
PI3Kα-E542K, Ki: 1.89 nM
p110γ, Ki: 179 nM
p110δ, Ki: 14.2 nM
          Pan Inhibitor >98.0%
CAL-130 Hydrochloride
p110β, IC50: 56 nM
p110α, IC50: 115 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM
          Pan Inhibitor 99.88%
PI3Kγ inhibitor 3
PI3Kβ, pIC50: 4.5
PI3Kα, pIC50: 5.1
PI3Kγ, pIC50: 9.1
PI3Kδ, pIC50: 6.5
PI3KC2α, pIC50: 5
PI3KC2β, pIC50: 7.5
PI3KC2γ, pIC50: 5.5
 
PI3KC3, pIC50: 5.1
Pan Inhibitor
CHMFL-PI3KD-317
PI3Kβ, IC50: 284 nM
PI3Kα, IC50: 62.6 nM
PI3Kγ, IC50: 202.7 nM
PI3Kδ, IC50: 6 nM
 
PIK3C2B, IC50: 882.3 nM
 
Vps34, IC50: 1801.7 nM
  Pan Inhibitor
PI3K/HDAC-IN-1
PI3Kβ, IC50: 101 nM
PI3Kα, IC50: 42 nM
PI3Kγ, IC50: 67 nM
PI3Kδ, IC50: 8.1 nM
          Pan Inhibitor
PI3K/mTOR Inhibitor-2
PI3Kβ, IC50: 34 nM
PI3Kα, IC50: 3.4 nM
PI3Kγ, IC50: 1 nM
PI3Kδ, IC50: 16 nM
          Pan Inhibitor
PI3K/mTOR Inhibitor-1
PI3Kβ, IC50: 376 nM
PI3Kα, IC50: 20 nM
PI3Kγ, IC50: 204 nM
PI3Kδ, IC50: 46 nM
          Pan Inhibitor
NVP-BAG956
PI3Kβ, IC50: 446 nM
PI3Kα, IC50: 56 nM
PI3Kγ, IC50: 117 nM
PI3Kδ, IC50: 35 nM
          Pan Inhibitor
PI3Kγ inhibitor 1
PI3Kβ, IC50: 10 μM
PI3Kα, IC50: 10 μM
PI3Kγ, IC50: 100 nM
PI3Kδ, IC50: 100 nM
          Pan Inhibitor
ON 146040
PI3Kβ, IC50: 3 μM
PI3Kα, IC50: 14 nM
PI3Kγ, IC50: 1 μM
PI3Kδ, IC50: 20 nM
          Pan Inhibitor
CAL-130
p110β, IC50: 56 nM
p110α, IC50: 115 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM
          Pan Inhibitor