1. Immunology/Inflammation
  2. PGE synthase

PGE synthase

PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development.

PGE synthase Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
  • HY-13283
    MF63 Inhibitor 98.94%
    MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.
  • HY-B0683
    Limaprost Agonist 99.76%
    Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor.
  • HY-10582
    Flurbiprofen Inhibitor 99.75%
    Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
  • HY-30235A
    Benzydamine hydrochloride Inhibitor 98.79%
    Benzydamine Hcl is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase and has notable in vitro antibacterial activity.
  • HY-100125
    Timegadine Inhibitor
    Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of prostaglandin synthetase which also inhibits cyclo-oxygenase (COX) and lipo-oxygenase.
  • HY-B0890
    Zomepirac sodium salt Inhibitor 99.40%
    Zomepirac sodium salt is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.
  • HY-B0550
    Bismuth Subsalicylate Inhibitor
    Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
  • HY-B0270
    Suprofen Inhibitor 99.44%
    Suprofen is a non-steroidal anti-inflammatory drug (NSAID).
  • HY-B0336
    Pranoprofen Inhibitor 98.48%
    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology.
  • HY-10439
    HPGDS inhibitor 1 Inhibitor 99.49%
    HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
  • HY-12791
    hPGDS-IN-1 Inhibitor
    hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.
  • HY-101587
    PGS-IN-1 Inhibitor
    PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
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