Signaling Pathway

PGE synthase

PGE synthase

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Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development.

PGE synthase Inhibitors & Modulators (14)

Product Name Catalog No. Brief Description
5-Aminosalicylic acid

HY-15027

5-Aminosalicylic acid is an anti-inflammatory compound.

Benzydamine hydrochloride

HY-30235A

Benzydamine Hcl is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase and has notable in vitro antibacterial activity.

Bismuth Subsalicylate

HY-B0550

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

Flurbiprofen

HY-10582

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.

HPGDS inhibitor 1

HY-10439

HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.

hPGDS-IN-1

HY-12791

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.

L-Arginine

HY-N0455

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

L-Arginine hydrochloride

HY-N0455A

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

Limaprost

HY-B0683

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor.

MF63

HY-13283

MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.

Pranoprofen

HY-B0336

Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology.

Sinensetin

HY-N0297

Sinensetin is a methylated flavone found in certain citrus fruits.

Suprofen

HY-B0270

Suprofen is a non-steroidal anti-inflammatory drug (NSAID).

Zomepirac sodium salt

HY-B0890

Zomepirac sodium salt is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.