1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. MMP
  4. MMP-13 Isoform

MMP-13

 

MMP-13 Related Products (29):

Cat. No. Product Name Effect Purity
  • HY-B0239
    Chloramphenicol
    Inducer 99.82%
    Chloramphenicol is an orally active, potent and broad-spectrum antibiotic.
  • HY-N1463
    Luteolin 7-O-glucuronide
    Inhibitor 99.80%
    Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
  • HY-12170A
    Prinomastat hydrochloride
    Inhibitor ≥98.0%
    Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively.
  • HY-N1454
    Apigenin-7-glucuronide
    Inhibitor 98.83%
    Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
  • HY-107394
    UK 356618
    Inhibitor 98.91%
    UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM.
  • HY-146218
    MMP-9-IN-5
    Inhibitor
    MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9.
  • HY-146217
    MMP-9-IN-4
    Inhibitor
    MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9.
  • HY-146216
    MMP-9-IN-3
    Inhibitor
    MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9.
  • HY-114091
    PF-00356231 hydrochloride
    Inhibitor 99.52%
    PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM).
  • HY-125166
    DB04760
    Inhibitor 98.45%
    DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM.
  • HY-19485
    XL-784
    Inhibitor 98.13%
    XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively.
  • HY-107428
    PD-166793
    Inhibitor ≥99.0%
    PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively).
  • HY-19677
    Cipemastat
    Inhibitor 99.49%
    Cipemastat is a potent, competitive inhibitor of human collagenases 1, 2 and 3 with Kis of 3.0, 4.4 and 3.4 nM, respectively.
  • HY-107639
    UK-370106
    Inhibitor ≥99.0%
    UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8.
  • HY-N2350
    Cynaropicrin
    Inhibitor
    Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively.
  • HY-120793
    CMC2.24
    Inhibitor
    CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway.
  • HY-124029
    BI-4394
    Inhibitor 99.91%
    BI-4394 (MMP13-IN-3) is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.
  • HY-122624
    MMP13-IN-2
    Inhibitor 99.85%
    MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor.
  • HY-12168
    Tanomastat
    Inhibitor ≥99.0%
    Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group.
  • HY-117970
    MMPI-1154
    Inhibitor 99.87%
    MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction.