Mca-KPLGL-Dap(Dnp)-AR-NH2

Name: Mca-KPLGL-Dap(Dnp)-AR-NH2
Brand: MedChemExpress
SKU: HY-P4931
Rating: 4.5 (1 reviews)

Cat. No.: HY-P4931 Purity: 99.72%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1. (Ex/Em=325 nm/400 nm)

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Mca-KPLGL-Dap(Dnp)-AR-NH2 화학구조

CAS No. : 720710-69-0

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Mca-KPLGL-Dap(Dnp)-AR-NH2:

Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA 견적 받기

1 Publications Citing Use of MCE Mca-KPLGL-Dap(Dnp)-AR-NH2

•Biochem Biophys Res Commun. 2025 Sep 18:786:152681. [Abstract]

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•Related Screening Libraries:

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View All MMP Isoform Specific Products:

View All Isoforms

MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

MMP-1

27.5 μM (Km)

MMP-8

MMP-13

5.2 μM (Km)

MMP-14

7.9 μM (Km)

In Vitro

Specificity of Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH26 for collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP (MMP-14) The constant (kcat/Km) increases by a factor of 2-9, or 3 times than FS-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1221.32

화학식

C₅₅H₈₀N₁₆O₁₆

CAS No.

720710-69-0

Appearance

Solid

Color

Light yellow to yellow

Sequence

{Mca}-Lys-Pro-Leu-Gly-Leu-{Dap(Dnp)}-Ala-Arg-NH2

Sequence Shortening

{Mca}-KPLGL-{Dap(Dnp)}-AR-NH2

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (81.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 10 mg/mL (8.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8188 mL	4.0939 mL	8.1879 mL
5 mM	0.1638 mL	0.8188 mL	1.6376 mL
10 mM	0.0819 mL	0.4094 mL	0.8188 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.72%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (253 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Neumann U, et al. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Anal Biochem. 2004 May 15;328(2):166-73. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.8188 mL	4.0939 mL	8.1879 mL	20.4697 mL
H₂O / DMSO	5 mM	0.1638 mL	0.8188 mL	1.6376 mL	4.0939 mL
DMSO	10 mM	0.0819 mL	0.4094 mL	0.8188 mL	2.0470 mL
	15 mM	0.0546 mL	0.2729 mL	0.5459 mL	1.3646 mL
	20 mM	0.0409 mL	0.2047 mL	0.4094 mL	1.0235 mL
	25 mM	0.0328 mL	0.1638 mL	0.3275 mL	0.8188 mL
	30 mM	0.0273 mL	0.1365 mL	0.2729 mL	0.6823 mL
	40 mM	0.0205 mL	0.1023 mL	0.2047 mL	0.5117 mL
	50 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.4094 mL
	60 mM	0.0136 mL	0.0682 mL	0.1365 mL	0.3412 mL
	80 mM	0.0102 mL	0.0512 mL	0.1023 mL	0.2559 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.