Referencia número: HY-L031

Small Molecule Immuno-Oncology Compound Library

88 Cited Publications

Revisión del cliente

Based on 88 publication(s) in Google Scholar

Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines.

MCE Small Molecule Immuno-Oncology Compound Library offers 807 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (88)
Documentation
Composition

Description & Advantages

• A unique collection of 807 bioactive tumor immunology compounds for high throughput screening (HTS) and high content screening (HCS).

• A useful tool for cancer research by activation of an antitumor immune response.

• Small molecule compounds targeting PD1/PD-L1, ROR, CCR, CXCR, Sting, IDO, TLR, etc.

• Bioactivity and safety confirmed by preclinical research and clinical trials, some have been approved by FDA.

• Structurally diverse, medicinally active, and cell permeable.

• More detailed compound information with structure, IC₅₀, and other chemical & biological data.

• NMR and HPLC validated to ensure high purity and quality.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 807 bioactive tumor immunology compounds supplied as pre-dissolved Solutions or Solid

Solution: 781 compounds supplied in 10 mM solution, 22 compounds supplied in 2 mM solution, 4 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice