Histone Methyltransferase

Histone Methyltransferase Related Products (102):

By Effects:	Inhibitors (97) Antagonists (5)

Cat. No.	Product Name	Effect	Purity

HY-13470

GSK126 Inhibitor 99.98%

GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC₅₀ of 9.9 nM.

GSK126	Inhibitor	99.98%
GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC₅₀ of 9.9 nM.

HY-13803

Tazemetostat	Inhibitor	99.76%
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat (EPZ-6438) inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat (EPZ-6438) inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat (EPZ-6438) inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat (EPZ-6438) also inhibits EZH1 with an IC₅₀ of 392 nM.

HY-15593

Pinometostat Inhibitor 99.92%

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a K_i of 80 pM.
HY-101563

GSK3326595 Inhibitor 99.55%

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC₅₀ of 6.2 nM.
HY-12186

3-Deazaneplanocin A hydrochloride Inhibitor 99.76%

3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.

Pinometostat	Inhibitor	99.92%
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a K_i of 80 pM.

GSK3326595	Inhibitor	99.55%
GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC₅₀ of 6.2 nM.

3-Deazaneplanocin A hydrochloride	Inhibitor	99.76%
3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.

HY-128717A

GSK3368715 dihydrochloride	Inhibitor	99.49%
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity.

HY-19615B

MS023 dihydrochloride	Inhibitor	99.49%
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

HY-109108A

Valemetostat tosylate	Inhibitor	99.91%
Valemetostat tosylate (DS-3201 tosylate) is a first-in-class EZH1/2 dual inhibitor, used in the research of relapsed/refractory peripheral T-cell lymphoma.

HY-13500

GSK343 Inhibitor 98.49%

GSK343 is a highly potent and selective EZH2 inhibitor with an IC₅₀ of 4 nM.
HY-13980

UNC0642 Inhibitor 99.81%

UNC0642 is a potent and selective G9a/GLP inhibitor, with an IC₅₀ of less than 2.5 nM.
HY-10587

BIX-01294 Inhibitor 98.61%

BIX-01294 is an inhibitor of G9a Histone Methyltransferase with an IC₅₀ of 1.9 μM.
HY-12727

EPZ015666 Inhibitor 99.83%

EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC₅₀ of 22 nM.

GSK343	Inhibitor	98.49%
GSK343 is a highly potent and selective EZH2 inhibitor with an IC₅₀ of 4 nM.

UNC0642	Inhibitor	99.81%
UNC0642 is a potent and selective G9a/GLP inhibitor, with an IC₅₀ of less than 2.5 nM.

BIX-01294	Inhibitor	98.61%
BIX-01294 is an inhibitor of G9a Histone Methyltransferase with an IC₅₀ of 1.9 μM.

EPZ015666	Inhibitor	99.83%
EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC₅₀ of 22 nM.

HY-19615

MS023	Inhibitor	99.50%
MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

HY-101564

JNJ-64619178 Inhibitor 99.02%

JNJ-64619178 is a selective, orally active and pseudo-irreversible PRMT5 inhibitor with an IC₅₀ of 0.14 nM. JNJ-64619178 has potent activity In lung cancer.
HY-15646

UNC1999 Inhibitor 99.47%

UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH1/2 with IC₅₀s of 10 nM and 45 nM, repectively.

JNJ-64619178	Inhibitor	99.02%
JNJ-64619178 is a selective, orally active and pseudo-irreversible PRMT5 inhibitor with an IC₅₀ of 0.14 nM. JNJ-64619178 has potent activity In lung cancer.

UNC1999	Inhibitor	99.47%
UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH1/2 with IC₅₀s of 10 nM and 45 nM, repectively.

HY-N2019

Chaetocin	Inhibitor	98.06%
Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC₅₀ of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC₅₀ of 4 μM.

HY-15227

EPZ004777 Inhibitor 99.46%

EPZ004777 is a potent, selective DOT1L inhibitor with an IC₅₀ of 0.4 nM.
HY-15650

SGC0946 Inhibitor 99.68%

SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.
HY-101117

EED226 Inhibitor 98.70%

EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC₅₀ of 22 nM.
HY-15226A

AZ505 ditrifluoroacetate Inhibitor 99.99%

AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC₅₀ of 0.12 μM.

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