Histone Methyltransferase

Histone Methyltransferase Related Products (76):

By Effects:	Inhibitors (72) Antagonists (4)

Cat. No.	Product Name	Effect	Purity

HY-13470

GSK126 Inhibitor 99.98%

GSK126 is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC₅₀ of 9.9 nM.
HY-13803

Tazemetostat Inhibitor 99.76%

Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor with K_i and IC₅₀ of 2.5 and 11 nM, respectively.
HY-13500

GSK343 Inhibitor 98.49%

GSK343 is a highly potent and selective EZH2 inhibitor with an IC₅₀ of 4 nM.
HY-13980

UNC0642 Inhibitor 99.81%

UNC0642 is a potent and selective G9a/GLP inhibitor, with an IC₅₀ of less than 2.5 nM.
HY-12186

3-Deazaneplanocin A hydrochloride Inhibitor 99.76%

3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.

GSK126	Inhibitor	99.98%
GSK126 is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC₅₀ of 9.9 nM.

Tazemetostat	Inhibitor	99.76%
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor with K_i and IC₅₀ of 2.5 and 11 nM, respectively.

GSK343	Inhibitor	98.49%
GSK343 is a highly potent and selective EZH2 inhibitor with an IC₅₀ of 4 nM.

UNC0642	Inhibitor	99.81%
UNC0642 is a potent and selective G9a/GLP inhibitor, with an IC₅₀ of less than 2.5 nM.

3-Deazaneplanocin A hydrochloride	Inhibitor	99.76%
3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.

HY-117421

CM-579	Inhibitor
CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC₅₀ values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

HY-101520

Dot1L-IN-1 Inhibitor

Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a K_i of 2 pM.

Dot1L-IN-1	Inhibitor
Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a K_i of 2 pM.

HY-111544

EML741	Inhibitor
EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC₅₀ of 23 nM, K_d of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC₅₀, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated.

HY-15593

Pinometostat Inhibitor 99.92%

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a K_i of 80 pM.
HY-101563

GSK3326595 Inhibitor 99.24%

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC₅₀ of 6.2 nM.
HY-10587

BIX-01294 Inhibitor 98.61%

BIX-01294 is an inhibitor of G9a Histone Methyltransferase with IC₅₀ of 1.9 μM.
HY-15646

UNC1999 Inhibitor 99.47%

UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH1/2 with IC₅₀s of 10 nM and 45 nM, repectively.
HY-15226A

AZ505 ditrifluoroacetate Inhibitor 99.99%

AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC₅₀ of 0.12 μM.
HY-15227

EPZ004777 Inhibitor 99.89%

EPZ004777 is a potent, selective DOT1L inhibitor with an IC₅₀ of 0.4 nM.
HY-101117

EED226 Inhibitor 98.70%

EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC₅₀ of 22 nM.
HY-19615

MS023 Inhibitor 99.50%

MS023 is a potent and cell-permeable protein arginine methyltransferases (PRMTs) inhibitor with IC₅₀s of 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8.

Pinometostat	Inhibitor	99.92%
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a K_i of 80 pM.

GSK3326595	Inhibitor	99.24%
GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC₅₀ of 6.2 nM.

BIX-01294	Inhibitor	98.61%
BIX-01294 is an inhibitor of G9a Histone Methyltransferase with IC₅₀ of 1.9 μM.

UNC1999	Inhibitor	99.47%
UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH1/2 with IC₅₀s of 10 nM and 45 nM, repectively.

AZ505 ditrifluoroacetate	Inhibitor	99.99%
AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC₅₀ of 0.12 μM.

EPZ004777	Inhibitor	99.89%
EPZ004777 is a potent, selective DOT1L inhibitor with an IC₅₀ of 0.4 nM.

EED226	Inhibitor	98.70%
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC₅₀ of 22 nM.

MS023	Inhibitor	99.50%
MS023 is a potent and cell-permeable protein arginine methyltransferases (PRMTs) inhibitor with IC₅₀s of 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8.

HY-N2019

Chaetocin	Inhibitor	>98.0%
Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC₅₀ of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC₅₀ of 4 μM.

HY-15650

SGC0946 Inhibitor 98.48%

SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.
HY-19324

EPZ031686 Inhibitor 99.63%

EPZ031686 is an orally available SMYD3 inhibitor with an IC₅₀ of 3 nM in cell-free assay.
HY-100235

EPZ015866 Inhibitor 99.98%

EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC₅₀ of 22 nM.

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