Histone Methyltransferase

Histone Methyltransferase Related Products (71):

By Effects:	Inhibitors (67) Antagonists (4)

Cat. No.	Product Name	Effect	Purity

HY-13470

GSK126 Inhibitor 99.86%

GSK126 is a potent, highly selective inhibitor of EZH2 methyltransferase activity with IC₅₀ of 9.9 nM.
HY-13803

EPZ-6438 Inhibitor 99.63%

EPZ-6438 inhibits the activity of human PRC2-containing wild-type EZH2 with K_i of 2.5±0.5 nM.
HY-13980

UNC0642 Inhibitor 99.81%

UNC0642 is a potent and selective G9a/GLP inhibitor, inhibits G9a/GLP with an IC₅₀ of less than 2.5 nM.
HY-13500

GSK343 Inhibitor 98.49%

GSK343 is a highly potent, selective, and cell-active EZH2 inhibitor with IC₅₀ of 4 nM.
HY-12186

3-Deazaneplanocin A hydrochloride Inhibitor 99.76%

3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.
HY-19563

A-893 Inhibitor

A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC₅₀ of 2.8 nM.
HY-111390

Dot1L-IN-2 Inhibitor

Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC₅₀ and K_i of 0.4 nM and 0.08 nM, respectively.
HY-12991A

BIX-01338 hydrate Inhibitor

BIX-01338 hydrate is a histone lysine methyltransferase inhibitor.

GSK126	Inhibitor	99.86%
GSK126 is a potent, highly selective inhibitor of EZH2 methyltransferase activity with IC₅₀ of 9.9 nM.

EPZ-6438	Inhibitor	99.63%
EPZ-6438 inhibits the activity of human PRC2-containing wild-type EZH2 with K_i of 2.5±0.5 nM.

UNC0642	Inhibitor	99.81%
UNC0642 is a potent and selective G9a/GLP inhibitor, inhibits G9a/GLP with an IC₅₀ of less than 2.5 nM.

GSK343	Inhibitor	98.49%
GSK343 is a highly potent, selective, and cell-active EZH2 inhibitor with IC₅₀ of 4 nM.

3-Deazaneplanocin A hydrochloride	Inhibitor	99.76%
3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.

A-893	Inhibitor
A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC₅₀ of 2.8 nM.

Dot1L-IN-2	Inhibitor
Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC₅₀ and K_i of 0.4 nM and 0.08 nM, respectively.

BIX-01338 hydrate	Inhibitor
BIX-01338 hydrate is a histone lysine methyltransferase inhibitor.

HY-15593

EPZ-5676	Inhibitor	99.75%
EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase with K_i of < 80 pM, demonstrating > 37,000-fold selectivity against all other PMTs tested, and inhibits H3K79 methylation in tumor.

HY-19324

EPZ031686 Inhibitor 99.63%

EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively.
HY-15646

UNC1999 Inhibitor 99.47%

UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2 (IC₅₀<10 nM) and EZH1 (IC₅₀=45±3 nM).
HY-15226A

AZ505 ditrifluoroacetate Inhibitor 99.99%

AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC₅₀ of 0.12 μM.

EPZ031686	Inhibitor	99.63%
EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively.

UNC1999	Inhibitor	99.47%
UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2 (IC₅₀<10 nM) and EZH1 (IC₅₀=45±3 nM).

AZ505 ditrifluoroacetate	Inhibitor	99.99%
AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC₅₀ of 0.12 μM.

HY-12727

EPZ015666	Inhibitor	98.56%
EPZ015666 is an orally available inhibitor of PRMT5 enzymatic activity in biochemical assays with IC₅₀ of 22 nM and broad selectivity against a panel of other histone methyltransferases.

HY-19313

LLY-507	Inhibitor	99.09%
LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets.

HY-15227

EPZ004777 Inhibitor 99.89%

EPZ004777 is a potent, selective DOT1L inhibitor with IC₅₀ of 0.4 nM.
HY-101563

GSK3326595 Inhibitor 99.24%

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad anti-proliferative activity.
HY-19615

MS023 Inhibitor 99.84%

MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM.
HY-15273

UNC0638 Inhibitor 99.87%

UNC0638 is a potent G9a (EHMT2) (IC₅₀<15 nM) and GLP (EHMT1) inhibitor (IC₅₀=19 nM) in S-adenosyl-L-homocysteine hydrolase (SAHH)-coupled assays.

EPZ004777	Inhibitor	99.89%
EPZ004777 is a potent, selective DOT1L inhibitor with IC₅₀ of 0.4 nM.

GSK3326595	Inhibitor	99.24%
GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad anti-proliferative activity.

MS023	Inhibitor	99.84%
MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM.

UNC0638	Inhibitor	99.87%
UNC0638 is a potent G9a (EHMT2) (IC₅₀<15 nM) and GLP (EHMT1) inhibitor (IC₅₀=19 nM) in S-adenosyl-L-homocysteine hydrolase (SAHH)-coupled assays.

HY-100235

EPZ015866	Inhibitor	98.71%
EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5. It maintained excellent selectivity against other PMT enzymes observed with EPZ015666 [1].

HY-12583

A-366	Inhibitor	98.47%
A-366 is a peptide-competitive inhibitor of G9a/GLP with an enzymatic IC50 of ~3 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets.

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