723754-14-1
Chemical Structure
WX2-43
- CAS. Nr.: 723754-14-1
- Formula:C17H21ClN2
- Molecular Weight:288.82
IUPAC Name: 4-(((4-chlorophenyl)amino)methyl)-N,N-diethylaniline
InChIKey: OKEBKDNDKRWCCC-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C=C1)NCC2=CC=C(C=C2)N(CC)CC
Biological Activity: WX2-43 is a PRMT5-KLF4 inhibitor (Kd of 11.0 nM). WX2-43 binds to the region between amino acids L400-M500 on PRMT5. WX2-43 efficiently intercepts the interaction between KLF4 and PRMT5, and blocks KLF4 methylation. WX2-43 decreases p21 levels and increases Bax levels. WX2-43 suppresses triple negative breast tumor progression. WX2-43 can be used in the research of triple-negative breast cancer and colorectal cancer[1][2].
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WX2-43 | 98.74% | WX2-43 is a PRMT5-KLF4 inhibitor (Kd of 11.0 nM). WX2-43 binds to the region between amino acids L400-M500 on PRMT5. WX2-43 efficiently intercepts the interaction between KLF4 and PRMT5, and blocks KLF4 methylation. WX2-43 decreases p21 levels and increases Bax levels. WX2-43 suppresses triple negative breast tumor progression. WX2-43 can be used in the research of triple-negative breast cancer and colorectal cancer. | ||||||||||||||||||||
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- [1]. Zhou Z, et al. A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy. EBioMedicine. 2019;44:98-111. [Content Brief]
- [2]. Borrelli C, et al. In vivo interaction screening reveals liver-derived constraints to metastasis. Nature. 2024;632(8024):411-418. [Content Brief]
Keywords
