1. Cell Cycle/DNA Damage
  2. IRE1


The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene. IRE1 is an endoplasmic reticulum (ER) transmembrane sensor that activates UPR to maintain ER and cellular function. While mammalian IRE1 promotes cell survive, it can initiate apoptosis via decay of anti-apoptotic microRNAs.

IRE1 activation is initiated by homotypic interactions of the stress-sensing lumenal domain favoring transautophosphorylation of the kinase-extension nuclease (KEN) domain on the cytoplasmic side of the ER membrane.

IRE1/XBP-1 has been shown to regulate a variety of genes in various cell types in response to ER stress, mostly related to ER function and the secretory pathway, although the target genes vary depending on the cell type and nature of the stress stimuli.

IRE1 Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-15845
    STF-083010 Inhibitor >98.0%
    STF-083010 is an Ire1 inhibitor.
  • HY-17537
    APY29 Inhibitor 99.44%
    APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
  • HY-19710
    MKC3946 Inhibitor >98.0%
    MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research.
  • HY-19707
    4μ8C Inhibitor 98.52%
    4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.