1. Cell Cycle/DNA Damage
  2. IRE1
  3. Toyocamycin

Toyocamycin (Synonyms: Vengicide)

Cat. No.: HY-103248
Handling Instructions

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage, with an IC50 of 80 nM. Toyocamycin (Vengicide) induces apoptosis. Toyocamycin (Vengicide) shows no effect on IRE1α auto-phosphorylation.

For research use only. We do not sell to patients.

Toyocamycin Chemical Structure

Toyocamycin Chemical Structure

CAS No. : 606-58-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 Get quote
50 mg USD 260 Get quote
100 mg USD 450 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage, with an IC50 of 80 nM. Toyocamycin (Vengicide) induces apoptosis. Toyocamycin (Vengicide) shows no effect on IRE1α auto-phosphorylation[1].

IC50 & Target

IC50: 80 nM (XBP1 activation)[1]

Molecular Weight

291.26

Formula

C₁₂H₁₃N₅O₄

CAS No.

606-58-6

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Toyocamycin
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