1. Cell Cycle/DNA Damage
    Anti-infection
  2. IRE1
    Fungal
    Antibiotic
  3. Toyocamycin

Toyocamycin (Synonyms: Vengicide)

Cat. No.: HY-103248 Purity: >99.0%
Handling Instructions

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage, with an IC50 of 80 nM. Toyocamycin (Vengicide) induces apoptosis. Toyocamycin (Vengicide) shows no effect on IRE1α auto-phosphorylation.

For research use only. We do not sell to patients.

Toyocamycin Chemical Structure

Toyocamycin Chemical Structure

CAS No. : 606-58-6

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10 mM * 1  mL in DMSO USD 55 Ask For Quote & Lead Time
5 mg USD 50 Ask For Quote & Lead Time
10 mg USD 75 Ask For Quote & Lead Time
50 mg USD 260 Ask For Quote & Lead Time
100 mg USD 450 Ask For Quote & Lead Time

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Description

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage, with an IC50 of 80 nM. Toyocamycin (Vengicide) induces apoptosis. Toyocamycin (Vengicide) shows no effect on IRE1α auto-phosphorylation[1].

IC50 & Target

IC50: 80 nM (XBP1 activation)[1]

Molecular Weight

291.26

Formula

C₁₂H₁₃N₅O₄

CAS No.

606-58-6

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

ToyocamycinVengicideIRE1FungalAntibioticInositol requiring enzyme 1Inhibitorinhibitorinhibit

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