Product Name |
CDK5 |
CDK1 |
CDK2 |
CDK3 |
CDK4 |
CDK6 |
CDK7 |
CDK8 |
CDK9 |
CDK14 |
CDK16 |
CDK5 Selectivity |
Purity |
Abemaciclib |
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
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CDK1/cyclinB1, IC50: 1627 nM
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CDK2/cyclinE, IC50: 504 nM
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Cdk4/cyclin D1, IC50: 2 nM
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CDK6/cyclinD1, IC50: 10 nM
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CDK7/Mat1/cyclinH1, IC50: 3910 nM
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CDK9/cyclinT1, IC50: 57 nM
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Pan Inhibitor
|
99.69% |
Abemaciclib methanesulfonate |
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
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CDK1/cyclinB1, IC50: 1627 nM
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CDK2/cyclinE, IC50: 504 nM
|
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Cdk4/cyclin D1, IC50: 2 nM
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CDK6/cyclinD1, IC50: 10 nM
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CDK7/Mat1/cyclinH1, IC50: 3910 nM
|
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CDK9/cyclinT1, IC50: 57 nM
|
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Pan Inhibitor
|
99.95% |
CDK5 inhibitor 20-223 |
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Pan Inhibitor
|
99.64% |
Dinaciclib |
|
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Pan Inhibitor
|
99.73% |
Seliciclib |
|
cdc2/cyclin B, IC50: 0.65 μM
|
cdk2/cyclin A, IC50: 0.7 μM
Cdk2/cyclin E2, IC50: 0.7 μM
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Pan Inhibitor
|
99.94% |
AZD-5438 |
|
cdk1-cyclin B1, IC50: 16 nM
|
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
|
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cdk4-cyclin D1, IC50: 449 nM
|
cdk6-cyclin D3, IC50: 21 nM
|
cdk7-cyclin H, IC50: 821 nM
|
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cdk9-cyclin T, IC50: 20 nM
|
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Pan Inhibitor
|
99.37% |
AT7519 |
|
Cdk1/cyclin B, IC50: 210 nM
|
cdk2/cyclin A, IC50: 47 nM
|
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Cdk4/cyclin D1, IC50: 100 nM
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cdk6/cyclin D3, IC50: 170 nM
|
CDK7/Cyclin H/MAT1, IC50: 2400 nM
|
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CDK9/Cyclin T, IC50: 10 nM
|
|
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Pan Inhibitor
|
99.40% |
GSK 3 Inhibitor IX |
|
Cdk1/cyclin B, IC50: 320 nM
|
cdk2/cyclin A, IC50: 300 nM
|
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Cdk4/cyclin D1, IC50: 10 μM
|
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Pan Inhibitor
|
99.66% |
Samuraciclib hydrochloride |
CDK5/p35NCK, IC50: 9.4 μM
|
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cdk2/cyclin A, IC50: 578 nM
|
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CDK7/cyclin H, IC50: 41 nM
|
|
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Pan Inhibitor
|
99.98% |
Kenpaullone |
|
Cdk1/cyclin B, IC50: 0.4 μM
|
cdk2/cyclin A, IC50: 0.68 μM
CDK2/cyclinE, IC50: 7.5 μM
|
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Pan Inhibitor
|
>97.0% |
THZ2 |
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Pan Inhibitor
|
99.62% |
CGP60474 |
|
CDK1-Cyclin B, IC50: 26 nM
|
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
|
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CDK4/cyclin D, IC50: 216 nM
|
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CDK7/cyclin H, IC50: 200 nM
|
|
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Pan Inhibitor
|
98.70% |
R547 |
|
Cdk1/cyclin B, Ki: 2 nM
Cdk1/cyclin B, IC50: 0.2 nM
|
CDK2/cyclinE, Ki: 3 nM
cdk2/cyclin A, IC50: 0.1 nM
CDK2/cyclinE, IC50: 0.4 nM
|
CDK3/Cyclin E, IC50: 0.8 nM
|
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cdk6/cyclin D3, IC50: 4 nM
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CDK7/cyclin H, IC50: 171 nM
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Pan Inhibitor
|
99.66% |
PHA-767491 hydrochloride |
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Pan Inhibitor
|
99.91% |
Purvalanol A |
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cdc2-cyclin B, IC50: 4 nM
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cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
|
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cdk4-cyclin D1, IC50: 850 nM
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Pan Inhibitor
|
99.11% |
PHA-793887 |
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Cdk1/cyclin B, IC50: 60 nM
|
cdk2/cyclin A, IC50: 8 nM
CDK2/cyclinE, IC50: 8 nM
|
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Cdk4/cyclin D1, IC50: 62 nM
|
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CDK7/cyclin H, IC50: 10 nM
|
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CDK9/cyclinT1, IC50: 138 nM
|
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Pan Inhibitor
|
99.95% |
Atuveciclib |
CDK5/p35(h), IC50: 1600 nM
|
CDK1/CycB(h), IC50: 1100 nM
|
CDK2/CycE(h), IC50: 1000 nM
|
CDK3/CycE(h), IC50: 890 nM
|
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CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
|
|
|
Pan Inhibitor
|
99.20% |
(R)-CR8 trihydrochloride |
|
CDK1/cyclinB1, IC50: 0.09 μM
|
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
|
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CDK7/cyclin H, IC50: 1.1 μM
|
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CDK9/Cyclin T, IC50: 0.18 μM
|
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Pan Inhibitor
|
99.02% |
NG 52 |
|
cdc2-cyclin B, IC50: 0.34 μM
|
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Pan Inhibitor
|
99.97% |
Lerociclib dihydrochloride |
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
|
CDK1/cyclinB1, IC50: 2.4 μM
|
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
|
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Cdk4/cyclin D1, IC50: 1 nM
|
cdk6/cyclin D3, IC50: 2 nM
|
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
|
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CDK9/Cyclin T, IC50: 28 nM
|
|
|
Pan Inhibitor
|
98.45% |
AT7519 Hydrochloride |
|
Cdk1/cyclin B, IC50: 210 nM
|
cdk2/cyclin A, IC50: 47 nM
|
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Cdk4/cyclin D1, IC50: 100 nM
|
cdk6/cyclin D3, IC50: 170 nM
|
CDK7/Cyclin H/MAT1, IC50: 2400 nM
|
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CDK9/Cyclin T, IC50: 10 nM
|
|
|
Pan Inhibitor
|
99.99% |
Purvalanol B |
|
cdc2/cyclin B, IC50: 6 nM
cyclin dependent kinase 1-cyclinB, IC50: 6 nM
|
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
|
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Cdk4/cyclin D1, IC50: 10000 nM
|
|
|
|
|
|
|
Pan Inhibitor
|
>97.0% |
MC180295 |
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
|
CDK1-Cyclin B, IC50: 138 nM
|
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
|
CDK3-Cyclin E, IC50: 399 nM
|
CDK4-Cyclin D, IC50: 112 nM
|
cdk6-cyclin D3, IC50: 712 nM
|
CDK7-CycH/MAT1, IC50: 555 nM
|
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CDK9- Cyclin T1, IC50: 5 nM
|
|
|
Pan Inhibitor
|
98.47% |
BS-181 hydrochloride |
|
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CDK2/Cyc E, IC50: 0.88 μM
|
|
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CDK7/CycH/MAT1, IC50: 0.021 μM
|
|
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|
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Pan Inhibitor
|
>99.0% |
(R)-CR8 |
|
Cdk1/cyclin B, IC50: 0.09 μM
|
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
|
|
|
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CDK7/cyclin H, IC50: 1.1 μM
|
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CDK9/Cyclin T, IC50: 0.18 μM
|
|
|
Pan Inhibitor
|
>98.0% |
JSH-150 |
|
Cdk1/cyclin B, IC50: 1.34 μM
|
cdk2/cyclin A, IC50: 2.86 μM
|
|
|
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CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
|
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CDK9/cyclinT1, IC50: 1 nM
|
CDK14/Cyclin Y, IC50: 1.68 μM
|
CDK16/Cyclin Y, IC50: 292 nM
|
Pan Inhibitor
|
98.36% |
PNU112455A hydrochloride |
|
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Pan Inhibitor
|
99.62% |
Alsterpaullone |
|
Cdk1/cyclin B, IC50: 35 nM
|
cdk2/cyclin A, IC50: 15 nM
CDK2/Cyc E, IC50: 200 nM
|
|
|
|
|
|
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|
Pan Inhibitor
|
>98.0% |
NVP-LCQ195 |
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
|
Cdk1/cyclin B, IC50: 2 nM
|
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
|
CDK3/Cyclin E, IC50: 42 nM
|
|
cdk6/cyclin D3, IC50: 187 nM
|
CDK7/Cyclin H/MAT1, IC50: 3564 nM
|
|
CDK9/cyclinT1, IC50: 15 nM
|
|
|
Pan Inhibitor
|
99.80% |
NU6140 |
|
CDK1-Cyclin B, IC50: 6.6 μM
|
cdk2-cyclin A, IC50: 0.41 μM
|
|
CDK4-Cyclin D, IC50: 5.5 μM
|
|
cdk7-cyclin H, IC50: 3.9 μM
|
|
|
|
|
Pan Inhibitor
|
>99.0% |
5-Iodo-indirubin-3'-monoxime |
|
Cdk1/cyclin B, IC50: 25 nM
|
|
|
|
|
|
|
|
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|
Pan Inhibitor
|
99.50% |
AT7519 trifluoroacetate |
|
Cdk1/cyclin B, IC50: 210 nM
|
cdk2/cyclin A, IC50: 47 nM
|
|
Cdk4/cyclin D1, IC50: 100 nM
|
cdk6/cyclin D3, IC50: 170 nM
|
CDK7/Cyclin H/MAT1, IC50: 2400 nM
|
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CDK9/Cyclin T, IC50: 10 nM
|
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Pan Inhibitor
|
98.16% |
Indirubin-3'-monoxime-5-sulphonic acid |
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Pan Inhibitor
|
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Indirubin-5-sulfonate |
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Cdk1/cyclin B, IC50: 55 nM
|
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
|
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Cdk4/cyclin D1, IC50: 300 nM
|
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Pan Inhibitor
|
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