1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7 Inhibitors

CDK7 Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform CDK7 together.

Please try each isoform separately.

CDK7 Specific Inhibitors
Product Name CDK7 CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK8 CDK9 CDK12 CDK13 CDK14 CDK16 CDK7 Selectivity Purity
THZ1
CDK7, IC50: 3.2 nM
                        Selective Inhibitor 98.82%
THZ1 Hydrochloride
CDK7, IC50: 3.2 nM
                        Selective Inhibitor 98.70%
CT7001 hydrochloride
CDK7/CycH/MAT1, IC50: 41 nM
 
CDK2/cycE1, IC50: 578 nM
                    Selective Inhibitor 99.98%
BS-181 hydrochloride
CDK7/CycH/MAT1, IC50: 0.021 μM
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
 
CDK9/cycT, IC50: 4.2 μM
        Selective Inhibitor
Abemaciclib methanesulfonate
CDK7/Mat1/cyclinH1, IC50: 3910 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
 
CDK9/cyclinT1, IC50: 57 nM
        Pan Inhibitor 99.95%
Abemaciclib
CDK7/Mat1/cyclinH1, IC50: 3910 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
 
CDK9/cyclinT1, IC50: 57 nM
        Pan Inhibitor 99.69%
SNS-032
CDK7, IC50: 62 nM
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
 
CDK4, IC50: 925 nM
     
CDK9, IC50: 4 nM
        Pan Inhibitor 98.50%
AZD-5438
cdk7-cyclin H, IC50: 821 nM
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
 
cdk9-cyclin T, IC50: 20 nM
        Pan Inhibitor 99.37%
AT7519
CDK7/Cyclin H/MAT1, IC50: 2400 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
 
CDK9/Cyclin T, IC50: 10 nM
        Pan Inhibitor 98.15%
Milciclib
cyclin H/CDK7, IC50: 150 nM
cyclin B/CDK1, IC50: 398 nM
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
 
cyclin D1/CDK4, IC50: 160 nM
                Pan Inhibitor 98.61%
CDKI-73
CDK7, IC50: 134.26 nM
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
 
CDK9, IC50: 5.78 nM
        Pan Inhibitor 99.58%
AT7519 Hydrochloride
CDK7/Cyclin H/MAT1, IC50: 2400 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
 
CDK9/Cyclin T, IC50: 10 nM
        Pan Inhibitor 99.99%
LY2857785
CDK7, IC50: 0.246 μM
           
CDK8, IC50: 0.016 μM
CDK9, IC50: 0.011 μM
        Pan Inhibitor 98.59%
Lerociclib dihydrochloride
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
 
CDK9/Cyclin T, IC50: 28 nM
        Pan Inhibitor 98.45%
MC180295
CDK7-CycH/MAT1, IC50: 555 nM
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
 
CDK9- Cyclin T1, IC50: 5 nM
        Pan Inhibitor 98.47%
Longdaysin
CDK7, IC50: 29 μM
                        Pan Inhibitor 99.92%
JSH-150
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
Cdk1/cyclin B, IC50: 1.34 μM
cdk2/cyclin A, IC50: 2.86 μM
   
Cdk5/p25, IC50: 4.64 μM
   
CDK9/cyclinT1, IC50: 1 nM
   
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
Pan Inhibitor 92.04%
NVP-LCQ195
CDK7/Cyclin H/MAT1, IC50: 3564 nM
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
 
CDK9/cyclinT1, IC50: 15 nM
        Pan Inhibitor 98.99%
AT7519 trifluoroacetate
CDK7/Cyclin H/MAT1, IC50: 2400 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
 
CDK9/Cyclin T, IC50: 10 nM
        Pan Inhibitor 98.16%
Roniciclib
CDK7/Cyclin H/MAT1, IC50: 25 nM
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK4/cyclin D, IC50: 11 nM
     
CDK9/cyclinT1, IC50: 5 nM
        Pan Inhibitor
NU6140
cdk7-cyclin H, IC50: 3.9 μM
CDK1-Cyclin B, IC50: 6.6 μM
cdk2-cyclin A, IC50: 0.41 μM
 
CDK4-Cyclin D, IC50: 5.5 μM
cdk5-p25, IC50: 15 μM
              Pan Inhibitor >99.0%
Lerociclib
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
 
CDK9/Cyclin T, IC50: 28 nM
        Pan Inhibitor
Garcinone C
CDK7
                        Pan Inhibitor
SY-1365
CDK7
                        default Inhibitor