1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Apoptosis
  3. CDK7-IN-3

CDK7-IN-3 

Cat. No.: HY-138293
Handling Instructions

CDK7-IN-3 is a selective CDK7 inhibitor with a KD of 0.059 nM. CDK7-IN-3 shows poor inhibition on CDK2 (Ki=390 nM), CDK9 (Ki=290 nM), CDK12 (Ki=78 nM). CDK7-IN-3 induce apoptosis in tumor cells and has antitumor activity.

For research use only. We do not sell to patients.

CDK7-IN-3 Chemical Structure

CDK7-IN-3 Chemical Structure

CAS No. : 2417302-07-7

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Description

CDK7-IN-3 is a selective CDK7 inhibitor with a KD of 0.059 nM. CDK7-IN-3 shows poor inhibition on CDK2 (Ki=390 nM), CDK9 (Ki=290 nM), CDK12 (Ki=78 nM). CDK7-IN-3 induce apoptosis in tumor cells and has antitumor activity[1].

IC50 & Target[1]

CDK7

0.059 nM (Kd)

CDK2

390 nM (Ki)

CDK9

290 nM (Ki)

CDK12

78 nM (Ki)

In Vitro

CDK7-IN-3 (compound 102; 126.4 pM-4 µM; 72 h) has an EC50 of 2.1 nM in HCC70 cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

490.46

Formula

C₂₃H₂₆F₃N₆OP

CAS No.

2417302-07-7

SMILES

N#CC1=C(P(C)(C)=O)C2=C(C=C1)C(C3=NC(N[[email protected]@H]4CNC(C)(C)CC4)=NC=C3C(F)(F)F)=CN2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CDK7-IN-3CDKApoptosisCyclin dependent kinaseInhibitorinhibitorinhibit

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CDK7-IN-3
Cat. No.:
HY-138293
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