1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4 Inhibitors

CDK4 Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform CDK4 together.

Please try each isoform separately.

CDK4 Specific Inhibitors
Product Name CDK4 CDK1 CDK2 CDK3 CDK5 CDK6 CDK7 CDK9 CDK4 Selectivity Purity
ON-013100
Cdk4/cyclin D1
              Selective Inhibitor 98.23%
Palbociclib
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
       
Cdk6/cyclin D2, IC50: 16 nM
    Pan Inhibitor 99.96%
Abemaciclib methanesulfonate
Cdk4/cyclin D1, IC50: 2 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
CDK9/cyclinT1, IC50: 57 nM
Pan Inhibitor 99.95%
Palbociclib hydrochloride
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
       
Cdk6/cyclin D2, IC50: 16 nM
    Pan Inhibitor 99.94%
Ribociclib
CDK4, IC50: 10 nM
       
CDK6, IC50: 39 nM
    Pan Inhibitor 99.85%
Flavopiridol
CDK4/Cyc D1, IC50: 100 nM
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
          Pan Inhibitor 99.72%
Palbociclib isethionate
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
       
Cdk6/cyclin D2, IC50: 16 nM
    Pan Inhibitor 99.96%
Abemaciclib
Cdk4/cyclin D1, IC50: 2 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
CDK9/cyclinT1, IC50: 57 nM
Pan Inhibitor 99.69%
PF-06873600
CDK4, Ki: 0.13 nM
 
CDK2, Ki: 0.09 nM
   
CDK6, Ki: 0.16 nM
    Pan Inhibitor 99.98%
SNS-032
CDK4, IC50: 925 nM
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
     
CDK7, IC50: 62 nM
CDK9, IC50: 4 nM
Pan Inhibitor 98.50%
Ribociclib succinate
CDK4, IC50: 10 nM
       
CDK6, IC50: 39 nM
    Pan Inhibitor 99.84%
AZD-5438
cdk4-cyclin D1, IC50: 449 nM
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
cdk9-cyclin T, IC50: 20 nM
Pan Inhibitor 99.37%
AT7519
Cdk4/cyclin D1, IC50: 100 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
CDK9/Cyclin T, IC50: 10 nM
Pan Inhibitor 98.15%
CVT-313
Cdk4/cyclin D1, IC50: 215 μM
Cdk1/cyclin B, IC50: 4.2 μM
cdk2/cyclin A, IC50: 0.5 μM
          Pan Inhibitor 99.76%
JNJ-7706621
Cdk4/cyclin D1, IC50: 253 nM
Cdk1/cyclin B, IC50: 9 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
CDK3/Cyclin E, IC50: 58 nM
 
CDK6/cyclinD1, IC50: 175 nM
    Pan Inhibitor 99.91%
GSK 3 Inhibitor IX
Cdk4/cyclin D1, IC50: 10 μM
Cdk1/cyclin B, IC50: 320 nM
cdk2/cyclin A, IC50: 300 nM
 
CDK5/p35, IC50: 80 nM
      Pan Inhibitor 99.66%
Milciclib
cyclin D1/CDK4, IC50: 160 nM
cyclin B/CDK1, IC50: 398 nM
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
     
cyclin H/CDK7, IC50: 150 nM
  Pan Inhibitor 98.61%
LDC000067
cdk4-cyclin D1, IC50: 9242 nM
cdk1-cyclin B1, IC50: 5513 nM
cdk2-cyclin A, IC50: 2441 nM
       
CDK9- Cyclin T1, IC50: 44 nM
Pan Inhibitor 98.14%
Purvalanol A
cdk4-cyclin D1, IC50: 850 nM
cdc2-cyclin B, IC50: 4 nM
cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
 
cdk5-p35, IC50: 75 nM
      Pan Inhibitor 98.66%
Trilaciclib hydrochloride
Cdk4/cyclin D1, IC50: 1 nM
       
cdk6/cyclin D3, IC50: 4 nM
    Pan Inhibitor 99.24%
CDKI-73
CDK4, IC50: 8.18 nM
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
   
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
CDK9, IC50: 5.78 nM
Pan Inhibitor 99.58%
R547
CDK4/cyclin D, Ki: 1 nM
Cdk1/cyclin B, Ki: 2 nM
CDK2/cyclinE, Ki: 3 nM
          Pan Inhibitor 98.42%
BMS-265246
CDK4/cycD, IC50: 230 nM
CDK1/cycB, IC50: 6 nM
CDK2/Cyc E, IC50: 9 nM
          Pan Inhibitor 97.47%
Flavopiridol Hydrochloride
CDK4/Cyc D1, IC50: 100 nM
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
          Pan Inhibitor 99.74%
AT7519 Hydrochloride
Cdk4/cyclin D1, IC50: 100 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
CDK9/Cyclin T, IC50: 10 nM
Pan Inhibitor 99.99%
SU9516
CDK4, IC50: 200 nM
CDK1, IC50: 40 nM
CDK2, IC50: 22 nM
          Pan Inhibitor 99.76%
Ribociclib hydrochloride
CDK4, IC50: 10 nM
       
CDK6, IC50: 39 nM
    Pan Inhibitor 99.83%
Lerociclib dihydrochloride
Cdk4/cyclin D1, IC50: 1 nM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
CDK9/Cyclin T, IC50: 28 nM
Pan Inhibitor 98.45%
MC180295
CDK4-Cyclin D, IC50: 112 nM
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
CDK9- Cyclin T1, IC50: 5 nM
Pan Inhibitor 98.47%
ON123300
Cdk4/cyclin D1, IC50: 3.87 nM
       
CDK6/cyclinD1, IC50: 9.82 nM
    Pan Inhibitor
Purvalanol B
Cdk4/cyclin D1, IC50: 10000 nM
cdc2/cyclin B, IC50: 6 nM
cyclin dependent kinase 1-cyclinB, IC50: 6 nM
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK5/p35, IC50: 6 nM
      Pan Inhibitor >97.0%
FN-1501
Cdk4/cyclin D1, IC50: 0.85 nM
 
cdk2/cyclin A, IC50: 2.47 nM
   
CDK6/cyclinD1, IC50: 1.96 nM
    Pan Inhibitor 98.41%
AMG 925
CDK4, IC50: 3 nM
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
   
CDK6, IC50: 8 nM
    Pan Inhibitor 99.33%
Ribociclib succinate hydrate
CDK4, IC50: 10 nM
       
CDK6, IC50: 39 nM
    Pan Inhibitor 99.00%
Voruciclib hydrochloride
CDK4/Cyc D1, Ki: 3.96 nM
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
     
CDK6/cycD1, Ki: 2.92 nM
 
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
Pan Inhibitor >98.0%
CDK4/6-IN-4
CDK4
       
CDK6
    Pan Inhibitor
AT7519 trifluoroacetate
Cdk4/cyclin D1, IC50: 100 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
CDK9/Cyclin T, IC50: 10 nM
Pan Inhibitor 98.16%
AMG 925 HCl
CDK4, IC50: 3 nM
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
   
CDK6, IC50: 8 nM
    Pan Inhibitor 98.01%
Roniciclib
CDK4/cyclin D, IC50: 11 nM
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
     
CDK7/Cyclin H/MAT1, IC50: 25 nM
CDK9/cyclinT1, IC50: 5 nM
Pan Inhibitor
BS-181 hydrochloride
CDK4/Cyc D1, IC50: 33 μM
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
CDK9/cycT, IC50: 4.2 μM
Pan Inhibitor
CDK4/6-IN-3
CDK4, Ki: 0.3 nM
CDK1, Ki: 110 nM
     
CDK6, Ki: 2.2 nM
    Pan Inhibitor
Riviciclib hydrochloride
cdk4-cyclin D1, IC50: 0.063 μM
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
   
cdk6-cyclin D3, IC50: 0.396 μM
 
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
Pan 98.33%
CDK9-IN-7
CDK4/cyclin D, IC50: 148 nM
       
CDK6/cyclinD, IC50: 145 nM
 
CDK9/cyclinT1, IC50: 11 nM
Pan Inhibitor
Riviciclib
cdk4-cyclin D1, IC50: 0.063 μM
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
   
cdk6-cyclin D3, IC50: 0.396 μM
 
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
Pan Inhibitor
NU6140
CDK4-Cyclin D, IC50: 5.5 μM
CDK1-Cyclin B, IC50: 6.6 μM
cdk2-cyclin A, IC50: 0.41 μM
 
cdk5-p25, IC50: 15 μM
 
cdk7-cyclin H, IC50: 3.9 μM
  Pan Inhibitor >99.0%
Lerociclib
Cdk4/cyclin D1, IC50: 1 nM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
CDK9/Cyclin T, IC50: 28 nM
Pan Inhibitor
CDK4/6-IN-2
CDK4, IC50: 2.7 nM
       
CDK6, IC50: 16 nM
    Pan Inhibitor 99.82%
(2S,3R)-Voruciclib hydrochloride
CDK4
CDK1
     
CDK6
 
CDK9
Pan Inhibitor
Abemaciclib Metabolites M2
CDK4, IC50: 1-3 nM
       
CDK6, IC50: 1-3 nM
    Pan Inhibitor
Nimbolide
CDK4
       
CDK6
    Pan Inhibitor
Indirubin-5-sulfonate
Cdk4/cyclin D1, IC50: 300 nM
Cdk1/cyclin B, IC50: 55 nM
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
 
CDK5/p35, IC50: 65 nM
      Pan Inhibitor