3110098-09-1
Chemical Structure
CDK4/6-IN-28
- CAS No.: 3110098-09-1
- Formula:C25H29N7
- Molecular Weight:427.54
InChIKey: GABHSTBMNKGPPJ-UHFFFAOYSA-N
SMILES: CC(C=C1)=CC=C1C2=NC3=CC=NN3C(NC4=CC=C(CN5CCN(CC)CC5)C=N4)=C2
Biological Activity: CDK4/6-IN-28 is a potent, orally active, and selective CDK4/6 inhibitor IC50 values of 14.02 and 10.03 nM, respectively. CDK4/6-IN-28 inhibits breast cancer cell colony formation, migration, and proliferation. CDK4/6-IN-28 induces G1-phase cell cycle arrest and apoptosis in breast cancer cells. CDK4/6-IN-28 exhibits tumor inhibitory activity in breast cancer xenograft mouse models. CDK4/6-IN-28 can be used for the research of breast cancer[1].
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CDK4/6-IN-28 | CDK4/6-IN-28 is a potent, orally active, and selective CDK4/6 inhibitor IC50 values of 14.02 and 10.03 nM, respectively. CDK4/6-IN-28 inhibits breast cancer cell colony formation, migration, and proliferation. CDK4/6-IN-28 induces G1-phase cell cycle arrest and apoptosis in breast cancer cells. CDK4/6-IN-28 exhibits tumor inhibitory activity in breast cancer xenograft mouse models. CDK4/6-IN-28 can be used for the research of breast cancer. | |||||||||||||||||||||
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Keywords
