Kininogen-1
Kininogen-1 (KNG1) is the multifunctional type 3 cystatin-family protein that serves as the precursor of bradykinin. Alternative splicing of a single gene yields high-molecular-weight kininogen (HK) and low-molecular-weight kininogen (LK); both contain three cystatin-like domains and a kinin segment, but only HK carries the additional histidine-rich region. HK is a cofactor of the plasma contact system, delivering prekallikrein and factor XI to negatively charged surfaces, and kallikrein then cleaves it to release bradykinin, driving vascular permeability, pain and inflammation. HK deficiency prolongs the activated partial thromboplastin time without causing bleeding. Recombinant kininogen domains support contact-system, kallikrein-inhibitor and bradykinin research.
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Kininogen-1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
