GM-CSFR
The granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is a heterodimeric class I cytokine receptor composed of a ligand-specific GM-CSFRα (CD116) subunit and a shared beta common chain (βc/CD131) that is also utilized by IL-3 and IL-5 receptors. GM-CSF first binds GM-CSFRα with low affinity; association with βc converts this into a high-affinity signaling complex that activates JAK2-STAT5, RAS-MAPK and PI3K pathways. The receptor is expressed on myeloid progenitors, neutrophils, eosinophils, monocytes, macrophages and dendritic cells. GM-CSFR signaling promotes proliferation and differentiation of granulocyte-macrophage progenitors, primes neutrophil oxidative burst and phagocytosis, drives macrophage activation, and supports alveolar macrophage and lung surfactant homeostasis. Excessive GM-CSF-GM-CSFR signaling underlies pulmonary alveolar proteinosis via anti-GM-CSF autoantibodies and contributes to rheumatoid arthritis inflammation, prompting development of GM-CSFR blockade (mavrilimumab) for inflammatory disease.
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GM-CSFR Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
