CD66d/CEACAM3
CD66d/CEACAM3 is a granulocyte-restricted member of the CEACAM family, carrying a single IgV-like extracellular domain and a short cytoplasmic tail with an ITAM-like motif. Unlike its relatives, CEACAM3 functions mainly as a pattern-recognition receptor for human-specific pathogens: it directly binds Opa proteins of Neisseria gonorrhoeae and Neisseria meningitidis, and the bound bacteria are engulfed through a Rac-dependent actin-remodeling process driven by its cytoplasmic tail. CD66d therefore represents a dedicated opsonin-independent phagocytic receptor of innate immunity. Its expression is essentially confined to neutrophils, which supports its use in myeloid immunophenotyping.
-
CD66d/CEACAM3 Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
