1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Other immune checkpoint molecules
  4. Butyrophilins

Butyrophilins (BTN family), similarly as the B7 family of regulatory proteins, belongs to the immunoglobulin (Ig) superfamily. Butyrophilins are glycoproteins contain two extracellular immunoglobulin domains, stabilized with disulfide bonds: constant IgC, and variable IgV and a transmembrane region. Butyrophilins are present on lymphocytes, dendritic cells, monocytes, macrophages, neutrophils and eosinophils, and acts as immune system regulators (stimulatory or inhibitory effect). In humans, BTN family includes 7 butyrophilin proteins (BTN1A1, BTN2A1, BTN2A2, BTN2A3, BTN3A1, BTN3A2, BTN3A3), 5 butyrophilin-like proteins (BTNL) (BTNL2, BTNL3, BTNL8, BTNL9, BTNL10) and the SKINT-like factor (SKINTL-selection and upkeep of intraepithelial T-cells), while in mice, 11 proteins of this family have been described: BTN1A1, BTN2A2, BTNL1, BTNL2, BTLN4, BTNL5, BTNL6, BTNL7, BTNL9, BTNL10 and SKINTL, which differ in humans and mice. Butyrophilins have been also demonstrated to play a role in various infections, e.g. tuberculosis or diseases that include sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis, genetic metabolic diseases, ulcerative colitis, cancer and kidney disease. Noteworthy, some BTN/BTNLs are co-inhibitory whereas others are co-stimulatory in the regard of conventional T cell function regulation. For instance, human BTN3A1 (CD277), mouse BTNL2 and murine BTNL1 are considered as co-inhibitory molecules; BTNL8 and BTN3A2 are recognized as co-stimulatory molecules.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity