1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    TGF-beta/Smad
  2. ROCK

ROCK

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus, invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, acoiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton.

ROCK Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-10583
    Y-27632 dihydrochloride Inhibitor 99.83%
    Y-27632 dihydrochloride is a cell-permeable, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively.
  • HY-10071
    Y-27632 Inhibitor 99.65%
    Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively.
  • HY-10341
    Fasudil Hydrochloride Inhibitor 99.91%
    Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Kis of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
  • HY-15307
    SLx-2119 Inhibitor 99.59%
    SLx-2119 is a selective inhibitor of ROCK2 with an IC50 of 105 nM.
  • HY-16563
    Narciclasine Activator 99.94%
    Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
  • HY-13257
    Thiazovivin Inhibitor 99.32%
    Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells.
  • HY-10069
    Y-33075 dihydrochloride Inhibitor
    Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.
  • HY-11000
    GSK429286A Inhibitor 99.13%
    GSK429286A is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.
  • HY-18990
    GSK180736A Inhibitor 98.05%
    GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
  • HY-15556
    GSK269962A Inhibitor 98.01%
    GSK269962A is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively.
  • HY-10319
    Azaindole 1 Inhibitor 99.46%
    Azaindole 1 is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively.
  • HY-15685
    Ripasudil Inhibitor 98.38%
    Ripasudil (K-115) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.
  • HY-15755
    RKI-1447 Inhibitor
    RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 values of 14.5 nM and 6.2 nM, respectively.
  • HY-13300
    SR-3677 Inhibitor 99.46%
    SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.
  • HY-15392
    Chroman 1 Inhibitor 99.76%
    Chroman 1 is a highly potent ROCK2 inhibitor, with an IC50 of 1 nM.
  • HY-15720A
    H-1152 dihydrochloride Inhibitor >98.0%
    H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
  • HY-12437
    BDP5290 Inhibitor >98.0%
    BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
  • HY-12659
    LX7101 Inhibitor 99.58%
    LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM.
  • HY-16071
    AT13148 Inhibitor 99.46%
    AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC50s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
  • HY-13911
    Hydroxyfasudil Inhibitor 98.13%
    Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
Isoform Specific Products

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