LASSBio-2382
LASSBio-2382 is a dual ROCK1/ROCK2 inhibitor with ROCK1 IC50 of 0.005 μM and ROCK2 IC50 of 0.003 μM. LASSBio-2382 inhibits viability and migration of cancer cells. LASSBio-2382 can be used for the research of triple-negative breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2487752-24-7
- Formula: C18H15N5O
- Molecular Weight:317.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ROCK1 0.05 μM (IC50) |
ROCK2 0.03 μM (IC50) |
LASSBio-2382 (Compound 17) potently inhibits both purified ROCK1 (IC50 = 0.005 μM) and ROCK2 (IC50 = 0.003 μM) in a cell-free biochemical assay[1].
LASSBio-2382 is insoluble in the PAMPA-BBB assay, precluding measurement of its blood-brain barrier permeability[1].
LASSBio-2382 (30 μM; 24 h) reduces MDA-MB-231 cell viability by 28.8%[1].
LASSBio-2382 (0.1-100 μM; 24 h) inhibits MDA-MB-231 cell migration in a dose-dependent manner, with inhibition reducing wound closure to <50% at 10 μM and <25% at 30 μM, and precipitation observed at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 human triple-negative breast adenocarcinoma cells
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Concentration:0.1 μM, 10 μM, 30 μM, 100 μM
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Incubation Time:24 h
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Result:Showed wound closure comparable to the control at 0.1 μM.
Reduced wound closure to less than 50% relative to the control at 10 μM.
Reduced wound closure to below 25% relative to the control at 30 μM.
Showed similar inhibition to 30 μM at 100 μM, with precipitation observed.
Chemical Information
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CAS No. 2487752-24-7
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Molecular Weight 317.34
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Formula C18H15N5O
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SMILES
O=C(CC1=CNC2=C1C=CC=C2)N/N=C/C3=CC(C=NN4)=C4C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LASSBio-2382 Related Classifications
HY-181582 Related Classifications
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