LFA-3/CD58
LFA-3, designated CD58, is a cell-surface glycoprotein of the immunoglobulin superfamily expressed on essentially all human nucleated cells and erythrocytes. Its two extracellular Ig-like domains bind CD2 on T lymphocytes and NK cells, forming one of the canonical costimulatory ligand-receptor pairs; the CD2-CD58 interaction strengthens antigen-independent adhesion and delivers signals that lower the activation threshold of T cells. CD58 exists mainly in a GPI-anchored form, with a minor transmembrane splice variant. Genetically, variants in the CD58 locus are among the strongest susceptibility factors for multiple sclerosis identified in genome-wide studies, linking adhesive signaling to autoimmune disease.
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LFA-3/CD58 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
