CD58 Protein, Cynomolgus (HEK293, His)
ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. CD58 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD58 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. CD58 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD58 protein, expressed by HEK293 , with C-His labeled tag.
Background
The ANGPTL7/Angiopoietin-related 7 protein assumes a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it acts as a mediator of dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue essential for the outflow of ocular aqueous humor and the maintenance of intraocular pressure. Additionally, ANGPTL7 serves as a negative regulator of angiogenesis in the cornea, playing a significant role in preserving corneal avascularity and transparency, as suggested by research findings. Structurally, it forms a homotetramer through disulfide linkages, further emphasizing its role in maintaining the structural integrity of the extracellular matrix in ocular tissues.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-His
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Accession
AOP17736.1 (I29-R215)
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Gene ID/
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Molecular Construction
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N-term
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CD58 (I29-R215)
Accession # AOP17736.1 -
His
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C-term
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Protein Length
Partial
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Synonyms
CD58; Ag3; Prev. LFA3; CD58 Antigen; CD58 Antigen, (Lymphocyte Function-Associated Antigen 3); CD58 Protein; Lymphocyte Function-Associated Antigen 3; LFA-3; Surface Glycoprotein LFA-3; CD58 Molecule; CD58 Antigen, (Lymphocyte Function-Associated Antigen
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AA Sequence
ISQQTYGILHKNVTFHVPSNIPLTEILWKKQKDKVAERENSEFRAFSSFKNRVYLDTVSGSLTIYNLTLSDEDEYEMESPNITDTMKFFLYVLEPLPSPTLTCALTNGSIEVQCMIPEHYNTHPQLNTYSWDCPLEQCKHNSTRIYFKMENDLPQKVQCTASNPLFKRTSSIIPETCIPSSGHSRER
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Predicted Molecular Mass
23 kDa
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Molecular Weight
Approximately 38-42 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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