CD58 Protein, Cynomolgus (HEK293, His)

ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. CD58 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD58 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD58 Protein, Cynomolgus (HEK293, His) is 215 a.a., with molecular weight of 38-42 kDa.

The ANGPTL7/Angiopoietin-related 7 protein assumes a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it acts as a mediator of dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue essential for the outflow of ocular aqueous humor and the maintenance of intraocular pressure. Additionally, ANGPTL7 serves as a negative regulator of angiogenesis in the cornea, playing a significant role in preserving corneal avascularity and transparency, as suggested by research findings. Structurally, it forms a homotetramer through disulfide linkages, further emphasizing its role in maintaining the structural integrity of the extracellular matrix in ocular tissues.

Cynomolgus

HEK293

C-His

F7HQR6 (M1-R215)

714204  [NCBI]

38-42 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.