Signaling Pathway

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Inhibitors & Modulators (34)

Product Name Catalog No. Brief Description
Angiotensin 1-7

HY-12403

Angiotensin (1-7) is a endogenous peptide fragment which can induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas.

Angiotensin II 5-valine

HY-P0108

Angiotensin II 5-valine is an angiotensin II analog which is an agonist at angiotensin receptors.

Angiotensin II human

HY-13948

Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

AVE 0991

HY-15778

AVE 0991 is a nonpeptide Ang-(1-7) receptor Mas agonist, represents an important step for exploration of the effects of Ang-(1-7) and testing of its potential as a cardiovascular drug.

AVE 0991 sodium salt

HY-15778A

AVE 0991 is a nonpeptide Ang-(1-7) receptor Mas agonist, represents an important step for exploration of the effects of Ang-(1-7) and testing of its potential as a cardiovascular drug.

Azilsartan

HY-14914

Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist  with IC50 of 2.6 nM.

Azilsartan D5

HY-14914S

Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.

Azilsartan medoxomil

HY-14736

Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of  0.62 nM, which used in the treatment of adults with essential hypertension.

Azilsartan medoxomil monopotassium

HY-17458

Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of  0.62 nM, which used in the treatment of adults with essential hypertension.

BIBS 39

HY-19732

BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.

Candesartan

HY-B0205

Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

Candesartan Cilexetil

HY-17505

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

Candesartan D4

HY-B0205S

Candesartan D4 is the deuterium labeled Candesartan, which is an angiotensin II receptor antagonist.

CGP-42112

HY-12405

CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.

EMA401

HY-13106

EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

Eprosartan mesylate

HY-15834A

Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.

Fimasartan

HY-B0780

Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure.

Irbesartan

HY-B0202

Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

Irbesartan D4

HY-B0202S

Irbesartan D4 is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.

LCZ696

HY-18204A

LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).