1. Signaling Pathways
  2. GPCR/G Protein
  3. Angiotensin Receptor

Angiotensin Receptor

Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Related Products (61):

Cat. No. Product Name Effect Purity
  • HY-13948
    Angiotensin II human Modulator 99.96%
    Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
  • HY-17512
    Losartan Antagonist 99.24%
    Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
  • HY-13955
    Telmisartan Antagonist 99.96%
    Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
  • HY-15778
    AVE 0991 Agonist 99.92%
    AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM.
  • HY-P0216
    A 779 Antagonist >98.0%
    A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.
  • HY-114412
    TD-0212 Antagonist
    TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.
  • HY-113035A
    Angiotensin III TFA Agonist
    Angiotensin III (TFA) is an angiotensin 1 (AT1) and AT2 receptor agonist.
  • HY-P1792
    Angiotensin II (1-4), human Agonist
    Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
  • HY-12403
    Angiotensin 1-7 Inhibitor 99.61%
    Angiotensin 1-7 (Ang-(1-7)) is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
  • HY-10259A
    PD 123319 ditrifluoroacetate Antagonist 99.82%
    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
  • HY-B0195
    Tranilast Inhibitor 99.60%
    Tranilast is an antiallergic agent.
  • HY-18204
    Valsartan Antagonist 99.35%
    Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.
  • HY-18204A
    LCZ696 Inhibitor 99.99%
    LCZ696 (Sacubitril mixture with Valsartan) is the first angiotensin receptor-neprilysin inhibitor (ARNi) to be used clinically. LCZ696 inhibits the nuclear transfer of NF-κB, JNK/p38MAPK phosphorylation, mitigates inflammation and apoptosis in diabetic mice and H9C2 cardiomyocytes under high-glucose (HG) conditions. LCZ696 is a combination of valsartan and AHU377, at a ratio of 1:1, which is synthesized through a complex chemical reaction, and it attenuats cardiac remodeling and dysfunction after myocardial infarction (MI) by reducing cardiac fibrosis and hypertrophy.
  • HY-17512A
    Losartan potassium Antagonist 99.91%
    Losartan (potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
  • HY-17004
    Olmesartan Antagonist 99.01%
    Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
  • HY-12405
    CGP-42112 Antagonist 98.82%
    CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.
  • HY-13106
    Olodanrigan Antagonist 99.29%
    Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
  • HY-B0205
    Candesartan Antagonist 98.34%
    Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
  • HY-B0780
    Fimasartan Antagonist 98.77%
    Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure.
  • HY-B0202
    Irbesartan Antagonist 99.79%
    Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.