1. GPCR/G Protein
    Apoptosis
  2. Angiotensin Receptor
    Apoptosis
  3. Candesartan Cilexetil

Candesartan Cilexetil (Synonyms: TCV-116)

Cat. No.: HY-17505 Purity: 99.77%
Handling Instructions

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

For research use only. We do not sell to patients.

Candesartan Cilexetil Chemical Structure

Candesartan Cilexetil Chemical Structure

CAS No. : 145040-37-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 65 In-stock
Estimated Time of Arrival: December 31
1 g USD 84 In-stock
Estimated Time of Arrival: December 31
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Description

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Target: Type-1 angiotensin II receptor Candesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects [1]. In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR [2].

Clinical Trial
Molecular Weight

610.66

Formula

C₃₃H₃₄N₆O₆

CAS No.

145040-37-5

SMILES

O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (81.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6376 mL 8.1879 mL 16.3757 mL
5 mM 0.3275 mL 1.6376 mL 3.2751 mL
10 mM 0.1638 mL 0.8188 mL 1.6376 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Candesartan CilexetilTCV-116TCV116TCV 116Angiotensin ReceptorApoptosisInhibitorinhibitorinhibit

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Candesartan Cilexetil
Cat. No.:
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