1. Signaling Pathways
  2. PROTAC
  3. Ligand for Target Protein

Ligand for Target Protein

The PROTAC molecule consists of a ligand, which binds the target protein, connected by a linker to another ligand that binds the E3 ubiquitin ligase.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Ligand for Target Protein Related Products (23):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107443
    PROTAC BRD4-binding moiety 2 1300019-38-8
    PROTAC BRD4-binding moiety 2 is a BRD4(1) inhibitor with an IC50 of 7.9 μM.
    PROTAC BRD4-binding moiety 2
  • HY-107445
    PROTAC BRD9-binding moiety 1 2097512-23-5
    PROTAC BRD9-binding moiety 1 is a compound that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
    PROTAC BRD9-binding moiety 1
  • HY-43723
    PROTAC BET-binding moiety 2 916493-82-8 98.85%
    PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain.
    PROTAC BET-binding moiety 2
  • HY-107451
    PROTAC BET-binding moiety 1 2093387-77-8
    PROTAC BET-binding moiety 1 is a key intermediate for the synthesis of high-affinity BET inhibitors.
    PROTAC BET-binding moiety 1
  • HY-111606
    DUPA 302941-52-2
    DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells.
    DUPA
  • HY-111847
    Androstanolone acetate 1164-91-6
    Androstanolone acetate is an androgen ligand, which targets androgen receptor (AR). Androstanolone acetate binds to cIAP1 ligand Bestatin via a linker to form PROTACs.
    Androstanolone acetate
  • HY-107447
    PROTAC Bcr-Abl-binding moiety 1 910297-51-7
    PROTAC Bcr-Abl-binding moiety 1 is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.
    PROTAC Bcr-Abl-binding moiety 1
  • HY-107452
    PROTAC FKBP12-binding moiety 1 1092369-24-8
    PROTAC FKBP12-binding moiety 1 is a synthetic ligand for FKBP (SLF), which is used in the synthesis of PROTACs.
    PROTAC FKBP12-binding moiety 1
  • HY-128845
    PROTAC CRBN Degrader-1 2358775-70-7
    PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader.
    PROTAC CRBN Degrader-1
  • HY-124625
    BI-4464 1227948-02-8 98.34%
    BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.
    BI-4464
  • HY-111852
    PROTAC ABL binding moiety 2 778277-37-5
    PROTAC ABL binding moiety 2, the GNF5 (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER.
    PROTAC ABL binding moiety 2
  • HY-111857
    PROTAC ABL binding moiety 4 2112837-79-1
    PROTAC ABL binding moiety 4, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER .
    PROTAC ABL binding moiety 4
  • HY-111849
    PROTAC ABL binding moiety 1 1436868-85-7
    PROTAC ABL binding moiety 1, the Imatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER.
    PROTAC ABL binding moiety 1
  • HY-111850
    PROTAC IAP binding moiety 1 339186-54-8
    PROTAC IAP binding moiety 1, the Bestatin (IAP ligand) moiety, binds to ABL inhibitor via a linker to form SNIPER.
    PROTAC IAP binding moiety 1
  • HY-111853
    PROTAC IAP binding moiety 2 2095244-62-3
    PROTAC IAP binding moiety 2, the MV-1 (IAP ligand) moiety, binds to ABL inhibitor via a linker to form SNIPER.
    PROTAC IAP binding moiety 2
  • HY-111823
    PROTAC BRD4-binding moiety 3 2098836-54-3
    PROTAC BRD4-binding moiety 3 is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC.
    PROTAC BRD4-binding moiety 3
  • HY-111843
    RAR ligand 1
    RAR ligand 1 is a retinoic acid ligand, which targets RAR. RAR ligand 1 binds to cIAP1 ligand Bestatin via a linker to form PROTACs.
    RAR ligand 1
  • HY-111845
    ERα ligand 1 138219-84-8
    ERα ligand 1 is an estrogen ligand, which targets estrogen receptor α (ERα). ERα ligand 1 binds to cIAP1 ligand Bestatin via a linker to form PROTACs.
    ERα ligand 1
  • HY-111856
    PROTAC IAP binding moiety 3 2095244-43-0
    PROTAC IAP binding moiety 3, the LCL161 derivative (IAP ligand) moiety, binds to ABL inhibitor via a linker to form SNIPER.
    PROTAC IAP binding moiety 3
  • HY-111855
    PROTAC ABL binding moiety 3
    PROTAC ABL binding moiety 3, the HG-7-85-01 (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER .
    PROTAC ABL binding moiety 3
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