1. Signaling Pathways
  2. PROTAC
  3. Ligand for Target Protein for PROTAC

Ligand for Target Protein for PROTAC

The PROTAC molecule consists of a ligand, which binds the target protein, connected by a linker to another ligand that binds the E3 ubiquitin ligase.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Ligand for Target Protein for PROTAC Related Products (24):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13030
    (+)-JQ-1 1268524-70-4 99.90%
    (+)-JQ-1 is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.
    (+)-JQ-1
  • HY-107443
    I-BET762 carboxylic acid 1300019-38-8
    I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.
    I-BET762 carboxylic acid
  • HY-111606
    DUPA 302941-52-2
    DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells.
    DUPA
  • HY-44103
    Desmethyl-QCA276 2126819-55-2
    Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM.
    Desmethyl-QCA276
  • HY-43723
    PROTAC BET-binding moiety 2 916493-82-8 98.85%
    PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain.
    PROTAC BET-binding moiety 2
  • HY-124625
    BI-4464 1227948-02-8 98.34%
    BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.
    BI-4464
  • HY-107445
    PROTAC BRD9-binding moiety 1 2097512-23-5
    PROTAC BRD9-binding moiety 1 is a compound that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
    PROTAC BRD9-binding moiety 1
  • HY-107451
    PROTAC BET-binding moiety 1 2093387-77-8
    PROTAC BET-binding moiety 1 is a key intermediate for the synthesis of high-affinity BET inhibitors.
    PROTAC BET-binding moiety 1
  • HY-12863B
    CPI-0610 carboxylic acid 1380089-81-5
    CPI-0610 carboxylic acid is a ligand for target protein for protact. CPI-0610 carboxylic acid is a potent bromodomain and extra-terminal (BET) protein inhibitor in the therapy of multiple myeloma.
    CPI-0610 carboxylic acid
  • HY-44012
    SMARCA-BD ligand 1 for Protac 1997319-92-2
    SMARCA-BD ligand 1 for Protac is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
    SMARCA-BD ligand 1 for Protac
  • HY-111847
    Androstanolone acetate 1164-91-6
    Androstanolone acetate is an androgen ligand, which targets androgen receptor (AR). Androstanolone acetate binds to cIAP1 ligand Bestatin via a linker to form PROTACs.
    Androstanolone acetate
  • HY-107447
    Dasatinib-C2-OH 910297-51-7
    Dasatinib-C2-OH (BMS-354825-C2-OH), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL.
    Dasatinib-C2-OH
  • HY-44012A
    SMARCA-BD ligand 1 for Protac dihydrochloride 2369053-68-7
    SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
    SMARCA-BD ligand 1 for Protac dihydrochloride
  • HY-107452
    SLF-amido-C2-COOH 1092369-24-8
    SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs.
    SLF-amido-C2-COOH
  • HY-114420
    AP1867-2-(carboxymethoxy) 2230613-03-1
    AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules.
    AP1867-2-(carboxymethoxy)
  • HY-111852
    GNF5-amido-Me 778277-37-5
    GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
    GNF5-amido-Me
  • HY-111857
    Dasatinib carbaldehyde 2112837-79-1
    Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
    Dasatinib carbaldehyde
  • HY-111849
    Imatinib carbaldehyde 1436868-85-7
    Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
    Imatinib carbaldehyde
  • HY-111843
    Ch55-O-C3-carbaldehyde
    Ch55-O-C3-carbaldehyde (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-carbaldehyde (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Ch55-O-C3-carbaldehyde
  • HY-111845
    Estrone-N-O-C1-amido 138219-84-8
    Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Estrone-N-O-C1-amido
Isoform Specific Products

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